Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Nutrients. 2018 Apr 13;10(4):481. doi: 10.3390/nu10040481.
Rheumatoid Arthritis (RA) is a chronic inflammatory disease. This study evaluates the effect of blue mussel intake on disease activity and quality of life in women with RA. Thirty-nine women with established RA and a disease activity score 28 (DAS28) >3.0 were recruited to a randomized 2 × 11-week cross-over dietary intervention. The participants continued with their medication and habitual diet and exchanged one cooked meal a day, five days a week, with a meal including 75 g blue mussels or 75 g meat. Diets were switched after an eight week washout period. Data regarding quality of life (SF-36), blood lipids, erythrocyte sediment rate (ESR), C-reactive protein (CRP) and tender and swollen joints were examined at the start and end of each dietary period. Thirty women completed one period, and twenty-three completed both. Intake of the blue mussel diet led to a significant reduction of DAS28-CRP ( = 0.048), but not DAS28. The number of EULAR (European League Against Rheumatism) criteria moderate and good responders were higher when consuming blue mussel diet ( = 0.036). Blood lipids did not change. To conclude, blue mussel intake reduced disease symptoms in women with RA and improved perceived health. The reported effects need to be confirmed by non-patient reported outcomes, such as inflammation markers.
类风湿关节炎（RA）是一种慢性炎症性疾病。本研究评估了食用贻贝对 RA 女性疾病活动度和生活质量的影响。招募了 39 名确诊的 RA 女性，疾病活动评分 28（DAS28）>3.0，进行了为期 2×11 周的交叉饮食干预随机对照试验。参与者继续服用药物和习惯性饮食，并每周五天交换一份包括 75 克贻贝或 75 克肉的餐食。在八周洗脱期后更换饮食。在每个饮食期开始和结束时，检查生活质量（SF-36）、血脂、红细胞沉降率（ESR）、C 反应蛋白（CRP）以及压痛和肿胀关节的数据。30 名妇女完成了一个周期，23 名妇女完成了两个周期。食用贻贝饮食可显著降低 DAS28-CRP（=0.048），但不能降低 DAS28。食用贻贝饮食时，达到 EULAR（欧洲抗风湿病联盟）标准的中度和良好反应者的数量更高（=0.036）。血脂没有变化。总之，贻贝摄入可减轻 RA 女性的疾病症状并改善健康感知。需要通过非患者报告的结果（如炎症标志物）来证实所报告的效果。
