Ngatu Nlandu Roger, Tanaka Mamoru, Ikeda Mitsunori, Inoue Masataka, Kanbara Sakiko, Nojima Sayumi
Graduate School of Health Sciences and Nursing, University of Kochi, Kochi 781-8515, Japan.
Department of Nutrition, University of Kochi, Kochi 781-8515, Japan.
J Funct Biomater. 2017 Aug 29;8(3):37. doi: 10.3390/jfb8030037.
Sujiaonori, a river alga growing in the Kochi prefecture, Japan, contains several bioactive compounds such as sulfated polysaccharides (ulvans), ω-3 fatty acids, and vitamins. Dietary intake of this alga-based supplement has been reported to increase circulatory adiponectin, a salutary hormone that is reported to be associated with healthy longevity and prevents a number of cardiovascular and metabolic disorders. This report highlights the anti-allergic and skin health enhancing effects of Sujiaonori-derived ulvan (Tosalvan) and supplement, respectively. RBL-2H3 cell line was used to investigate the anti-allergic effect of algal SP through the evaluation of β-hexosaminidase activity. Algal sulfated polysaccharides or SP (Tosalvan, Yoshino SP) were extracted from powders of dried alga samples provided by local food manufacturers. Report on the effect of daily dietary intake of Sujiaonori-based supplement on skin health is part of a four-week clinical investigation that, in comparison with a supplement made of 70% corn starch powder and 30% spinach powder mixture (twice 3 g daily), explore the beneficial effects of Sujiaonori algal biomaterial (SBM; 3 g taken twice daily) on cardiovascular, gastrointestinal and skin health in a sample of Japanese women. Transepidermal water loss (TEWL) was the skin health marker used in this study and was measured with the use of a corneometer. Significant reduction of β-hexosaminidase activity was observed in Tosalvan and Yoshino SP-treated cells (vs. control; < 0.05), whereas dietary intake of SBM markedly reduced TEWL level after four weeks of supplementation, as compared to baseline TEWL ( < 0.001). Additionally, SBM improved TEWL better than the control product ( < 0.001). Findings contained in this report suggest that Sujiaonori-derived Tosalvan and Yoshino SP have anti-allergic potential and that the dietary intake of SBM has a beneficial effect on skin health.
巢菜（Sujiaonori）是一种生长在日本高知县河流中的藻类，含有多种生物活性化合物，如硫酸化多糖（石莼聚糖）、ω-3脂肪酸和维生素。据报道，摄入这种以藻类为基础的补充剂可增加循环脂联素，这是一种有益的激素，据报道与健康长寿相关，并可预防多种心血管和代谢紊乱。本报告分别强调了巢菜衍生的石莼聚糖（Tosalvan）和补充剂的抗过敏和增强皮肤健康的作用。RBL-2H3细胞系用于通过评估β-己糖胺酶活性来研究藻类硫酸化多糖的抗过敏作用。藻类硫酸化多糖或SP（Tosalvan、吉野SP）从当地食品制造商提供的干燥藻类样品粉末中提取。关于每日摄入以巢菜为基础的补充剂对皮肤健康影响的报告是一项为期四周的临床研究的一部分，该研究将其与由70%玉米淀粉粉末和30%菠菜粉末混合物制成的补充剂（每天两次，每次3克）进行比较，探讨巢菜藻类生物材料（SBM；每天两次，每次3克）对日本女性样本的心血管、胃肠道和皮肤健康的有益影响。经皮水分流失（TEWL）是本研究中使用的皮肤健康指标，使用角质计进行测量。在Tosalvan和吉野SP处理的细胞中观察到β-己糖胺酶活性显著降低（与对照组相比；<0.05），而摄入SBM四周后，与基线TEWL相比，TEWL水平显著降低（<0.001）。此外，SBM改善TEWL的效果优于对照产品（<0.001）。本报告中的研究结果表明，巢菜衍生的Tosalvan和吉野SP具有抗过敏潜力，摄入SBM对皮肤健康有有益影响。
