海洋海绵 Hippospongia lachne 中的罕见抗过敏二萜
Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne.
机构信息
Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
出版信息
Sci Rep. 2017 Feb 22;7:43138. doi: 10.1038/srep43138.
Hipposponlachnins A (1) and B (2), possessing an unprecedented tetracyclo [9.3.0.0.0] tetradecane ring system, and the probable biogenetic precursor [3, (1R*,2E,4R*,7E,10S*,11S*,12R*)-10, 18-diacetoxydolabella-2,7-dien-6-one] of 1‒2 were isolated from the South China Sea marine sponge Hippospongia lachne. The structures of the novel compounds were determined using integrated spectroscopic methods in combination with single-crystal X-ray diffraction analysis. Compounds 1‒2 showed potent inhibitory activity on the release of β-hexosaminidase, a biomarker for degranulation, as well as the production of pro-inflammatory cytokine IL-4 and lipid mediator LTB in DNP-IgE-stimulated RBL-2H3 cells.
希波斯蓬拉奇宁 A（1）和 B（2），具有前所未有的四环[9.3.0.0.0]十四烷环系统，以及可能的生物发生前体[3，（1R*，2E，4R*，7E，10S*，11S*，12R*）-10,18-二乙酰氧基多贝拉-2,7-二烯-6-酮]，从南海海洋海绵希波斯蓬尼亚拉奇纳分离得到。新化合物的结构通过综合光谱方法结合单晶 X 射线衍射分析确定。化合物 1-2 对 DNP-IgE 刺激的 RBL-2H3 细胞中β-己糖胺酶（脱粒的生物标志物）的释放以及促炎细胞因子 IL-4 和脂质介质 LTB 的产生具有很强的抑制活性。
Zotero 插件