Temgoua Mazou N, Danwang Celestin, Agbor Valirie Ndip, Noubiap Jean Jacques
Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences,University of Yaoundé I, Yaoundé, Cameroon.
BMJ Open. 2017 Aug 28;7(8):e016412. doi: 10.1136/bmjopen-2017-016412.
Chronic kidney disease (CKD) is a global public health problem, with cardiovascular disease (CVD) being the major cause of mortality in these patients. Despite a high burden of CKD among patients in low/middle-income countries (LMICs), evidence on the distribution of CVD among these patients is lacking. This review seeks to determine the prevalence, incidence and mortality risks of CVD in patients with CKD in LMICs.
A systematic search of Medline, Scopus, Embase, Cumulative Index of Nursing and Allied Health and WHO Global Health Library databases for published studies reporting on the prevalence, incidence and associated mortality risk of CVD in CKD patients in LMICs will be conducted from 1 May 1987 to 1 July 2017 with no language restriction. Two authors will independently screen, select studies, extract data and assess the risk of bias in each study. Clinically homogeneous studies will be pooled after assessing for clinical and statistical heterogeneity using the χ test on Cochrane's Q statistic which is quantified by I values; assuming that I values of 25%, 50% and 75% represent low, medium and high heterogeneity, respectively. Funnel-plot analysis and Egger's test will be used to detect publication bias. Results will be presented according to WHO Regions (Africa, Americas, Eastern Mediterranean, Europe, South-East Asia and Western Pacific).
This proposed study will not require ethical approval as it will be based on published data. We will publish the final report of this review in a peer-reviewed journal, and the findings will be disseminated to the appropriate health authorities.
慢性肾脏病（CKD）是一个全球性的公共卫生问题，心血管疾病（CVD）是这些患者死亡的主要原因。尽管中低收入国家（LMICs）的患者中CKD负担沉重，但缺乏关于这些患者中CVD分布情况的证据。本综述旨在确定LMICs中CKD患者CVD的患病率、发病率和死亡风险。
将对Medline、Scopus、Embase、护理及相关健康累积索引和世界卫生组织全球健康图书馆数据库进行系统检索，以查找1987年5月1日至2017年7月1日期间发表的关于LMICs中CKD患者CVD患病率、发病率及相关死亡风险的研究，无语言限制。两名作者将独立筛选、选择研究、提取数据并评估每项研究的偏倚风险。在使用Cochrane Q统计量的χ检验评估临床和统计异质性后，将对临床同质的研究进行合并，该统计量由I值量化；假设I值为25%、50%和75%分别代表低、中、高异质性。将使用漏斗图分析和Egger检验来检测发表偏倚。结果将根据世界卫生组织区域（非洲、美洲、东地中海、欧洲、东南亚和西太平洋）呈现。
本拟议研究无需伦理批准，因为它将基于已发表的数据。我们将在同行评审期刊上发表本综述的最终报告，并将研究结果传播给适当的卫生当局。
