全球艾滋病毒感染人群中高血压的患病率和发病率：一项系统评价和荟萃分析方案

Prevalence and incidence of hypertension in the global HIV-infected population: a systematic review and meta-analysis protocol.

作者信息

Bigna Jean Joel, Tankeu Aurel T, Kaze Arnaud D, Noubiap Jean Jacques, Nansseu Jobert Richie

机构信息

Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, Yaoundé, Cameroon.

Faculty of Medicine, University of Paris-Sud XI, Le Kremlin-Bicêtre, France.

出版信息

BMJ Open. 2017 Oct 12;7(10):e016531. doi: 10.1136/bmjopen-2017-016531.

DOI:10.1136/bmjopen-2017-016531

PMID:29025833

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5652496/

Abstract

INTRODUCTION

Hypertension, representing one of the most frequent cardiovascular risk factors, is thought to increase in individuals living with HIV as well as in general population, but summarised global data on the topic are scarce. We conduct this systematic review and meta-analysis to assess the prevalence/incidence of hypertension in the global HIV-infected population.

METHODS AND ANALYSIS

This review will include observational studies conducted among HIV-infected people, which reported prevalence/incidence of hypertension or enough data for its appraisal. We will consider published and unpublished studies from 1 January 2007 to 31 May 2017. Relevant records will be searched using PubMed/Medline, Global Index Medicus, Web of Science and EMBASE. Reference lists of eligible papers and relevant review articles will be screened. Two investigators will independently screen, select studies and extract data, with discrepancies resolved by consensus or by arbitration of a third investigator. Methodological quality of the included studies will be assessed using the scale developed by Hoy and colleagues. Funnel plots and Egger's test will be used to determine publication bias. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate. To keep the effect of studies with extremely small or extremely large estimates on the overall estimate to a minimum, the variance of the study-specific prevalence/incidence will be stabilised with the Freeman-Tukey single arcsine transformation. The heterogeneity will be evaluated by the χ² test on Cochrane's Q statistic. Results will be presented by geographic region, income and antiretroviral therapy status.

ETHICS AND DISSEMINATION

This study is based on published data; therefore, ethical approval is not a requirement. The final report of this study in the form of a scientific paper will be published in peer-reviewed journals.

TRIAL REGISTRATION NUMBER

CRD42016051684.

摘要

引言

高血压是最常见的心血管危险因素之一，被认为在HIV感染者以及普通人群中都有增加，但关于该主题的全球汇总数据稀缺。我们进行这项系统评价和荟萃分析，以评估全球HIV感染人群中高血压的患病率/发病率。

方法与分析

本评价将纳入在HIV感染者中开展的观察性研究，这些研究报告了高血压的患病率/发病率或有足够数据进行评估。我们将考虑2007年1月1日至2017年5月31日期间发表和未发表的研究。将使用PubMed/Medline、全球医学索引、科学网和EMBASE检索相关记录。将筛选符合条件论文的参考文献列表和相关综述文章。两名研究者将独立筛选、选择研究并提取数据，分歧通过共识解决或由第三名研究者仲裁。将使用Hoy及其同事制定的量表评估纳入研究的方法学质量。将使用漏斗图和Egger检验确定发表偏倚。将通过随机效应荟萃分析模型汇总研究特异性估计值，以获得总体汇总估计值。为了将估计值极小或极大的研究对总体估计值的影响降至最低，将使用Freeman-Tukey单反正弦变换稳定研究特异性患病率/发病率的方差。将通过基于Cochrane Q统计量的χ²检验评估异质性。结果将按地理区域、收入和抗逆转录病毒治疗状况呈现。