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通过整合分析与植物防御相关的特化代谢途径揭示生化创新的进化途径。

Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway.

机构信息

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States.

Department of Plant Biology, Michigan State University, East Lansing, United States.

出版信息

Elife. 2017 Aug 30;6:e28468. doi: 10.7554/eLife.28468.

DOI:10.7554/eLife.28468
PMID:28853706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5595436/
Abstract

The diversity of life on Earth is a result of continual innovations in molecular networks influencing morphology and physiology. Plant specialized metabolism produces hundreds of thousands of compounds, offering striking examples of these innovations. To understand how this novelty is generated, we investigated the evolution of the Solanaceae family-specific, trichome-localized acylsugar biosynthetic pathway using a combination of mass spectrometry, RNA-seq, enzyme assays, RNAi and phylogenomics in different non-model species. Our results reveal hundreds of acylsugars produced across the Solanaceae family and even within a single plant, built on simple sugar cores. The relatively short biosynthetic pathway experienced repeated cycles of innovation over the last 100 million years that include gene duplication and divergence, gene loss, evolution of substrate preference and promiscuity. This study provides mechanistic insights into the emergence of plant chemical novelty, and offers a template for investigating the ~300,000 non-model plant species that remain underexplored.

摘要

地球上生命的多样性是分子网络不断创新的结果，这些创新影响着形态和生理学。植物特化代谢产生了成千上万种化合物，为这些创新提供了显著的例子。为了了解这种新颖性是如何产生的，我们使用质谱、RNA-seq、酶测定、RNAi 和不同非模式物种中的系统发生基因组学，研究了茄科家族特有的毛状体定位酰基糖生物合成途径的进化。我们的结果揭示了在茄科家族中甚至在单一植物中产生的数百种酰基糖，它们建立在简单的糖核上。在过去的 1 亿年中，相对较短的生物合成途径经历了多次创新循环，包括基因复制和分化、基因丢失、底物偏好和变异性的进化。这项研究为植物化学新颖性的出现提供了机制上的见解，并为研究仍未被充分探索的约 30 万种非模式植物物种提供了模板。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36d4/5595436/3f0a9bf6a302/elife-28468-fig3.jpg
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