a Danish Dementia Research Centre, Department of Neurology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.
b Department of Psychology , University of Copenhagen , Copenhagen , Denmark.
Clin Neuropsychol. 2017 Jan-Dec;31(sup1):72-87. doi: 10.1080/13854046.2017.1371337. Epub 2017 Aug 30.
The purpose of the present study was to develop a Danish adaptation of the Boston Naming Test (BNT) including a shortened 30-item version of the BNT for routine clinical use and two parallel 15-item versions for screening purposes.
The Danish adaptation of the BNT was based on ranking of items according to difficulty in a sample of older non-patients (n = 99). By selecting those items with the largest discrepancy in difficulty for non-patients compared to a mild Alzheimer's disease (AD) sample (n = 53), the shortened versions of the BNT were developed. Using an overlapping cells approach preliminary education and age norms for older Danes were constructed.
The Danish adaptation of the BNT had adequate reliability and the short versions were all highly correlated with the full 60-item BNT (BNT-60). The sensitivity and specificity of the BNT-60 was .83 and .86, respectively. The shortened versions displayed some reduction in sensitivity (.70-.77) but similar or better specificity (.86-.91). Post-test probabilities of mild AD associated with performances along selected score ranges of the BNT were estimated. Likelihood ratios were presented that can be combined with information regarding the base rate of AD in any setting in order to assist in interpreting the clinical significance of a given performance.
The short Danish versions of the BNT were highly correlated with the full BNT indicating that they measure the same construct. The Danish versions had acceptable diagnostic accuracy discriminating between mild AD and older non-patients.
本研究旨在开发丹麦版波士顿命名测试(BNT),包括用于常规临床使用的 30 项简短版 BNT 和用于筛查目的的两个平行的 15 项版本。
丹麦版 BNT 的改编基于对非患者样本(n=99)中项目难度的排序。通过选择与轻度阿尔茨海默病(AD)样本(n=53)相比,非患者在难度上差异最大的项目,开发了 BNT 的简短版本。使用重叠单元格方法,为丹麦老年人构建了初步教育和年龄的标准。
丹麦版 BNT 的可靠性适中,简短版本与完整的 60 项 BNT(BNT-60)高度相关。BNT-60 的敏感性和特异性分别为 0.83 和 0.86。简短版本的敏感性略有降低(0.70-0.77),但特异性相似或更好(0.86-0.91)。根据 BNT 中选定分数范围的表现,估计了与轻度 AD 相关的后测概率。提出了似然比,可以与任何环境中 AD 的基础发生率信息结合使用,以帮助解释特定表现的临床意义。
丹麦版 BNT 的简短版本与完整的 BNT 高度相关,表明它们测量的是相同的结构。丹麦版具有可接受的诊断准确性,可区分轻度 AD 和老年非患者。