FGF 信号通路：在耳蜗发育中的多种作用。
FGF signaling: diverse roles during cochlear development.
机构信息
Mary & Dick Holland Regenerative Medicine Program, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Mary & Dick Holland Regenerative Medicine Program, and Department of Developmental Neuroscience, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska, USA.
出版信息
BMB Rep. 2017 Oct;50(10):487-495. doi: 10.5483/bmbrep.2017.50.10.164.
Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development. [BMB Reports 2017; 50(10): 487-495].
哺乳动物内耳由六个感觉器官组成；耳蜗、前庭、椭圆囊和三个半规管。耳蜗包含感觉上皮，称为科蒂器，通过机械感觉毛细胞感知声音。哺乳动物内耳在发育过程中经历一系列形态发生，从后脑附近的外胚层增厚开始。这些事件需要包括 FGF、Wnt、Notch 和 Bmp 信号在内的多个信号级联的紧密调节。在这篇综述中，我们将讨论新出现的信号分子 FGF 信号在耳蜗发育中所必需的作用。[BMB 报告 2017；50(10)：487-495]。
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