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哪些代谢前体增加了子痫前期的风险，以及如何进一步研究这些代谢前体。

What are the metabolic precursors which increase the risk of pre-eclampsia and how could these be investigated further.

机构信息

Maternal & Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK; St Mary's Hospital, Central Manchester Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9PL, UK.

出版信息

Placenta. 2017 Dec;60:110-114. doi: 10.1016/j.placenta.2017.08.011. Epub 2017 Aug 24.

DOI:10.1016/j.placenta.2017.08.011
PMID:28855067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5730540/
Abstract

Several maternal and pregnancy characteristics have been associated with an increased risk of preeclampsia in epidemiological studies. This review discusses metabolic risk factors in particular and their interaction with other maternal and/or pregnancy characteristics. Examples of research studies that have used data from women with specific characteristics or explored the interaction between risk factors are discussed. Suggestions for future research using large data sets and incorporating knowledge of cardiovascular disease and other metabolic diseases are also highlighted.

摘要

在流行病学研究中，一些母体和妊娠特征与子痫前期的风险增加有关。这篇综述特别讨论了代谢危险因素及其与其他母体和/或妊娠特征的相互作用。讨论了使用具有特定特征的女性数据或探索危险因素之间相互作用的研究示例。还强调了使用大型数据集并结合心血管疾病和其他代谢性疾病知识进行未来研究的建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bc/5730540/bc53e7e69580/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bc/5730540/bc53e7e69580/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bc/5730540/bc53e7e69580/gr1.jpg

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本文引用的文献

1
Clinical and biochemical factors associated with preeclampsia in women with obesity.肥胖女性子痫前期相关的临床和生化因素。
Obesity (Silver Spring). 2017 Feb;25(2):460-467. doi: 10.1002/oby.21715. Epub 2016 Dec 23.
2
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies.孕早期确定的子痫前期临床危险因素：大型队列研究的系统评价和荟萃分析
BMJ. 2016 Apr 19;353:i1753. doi: 10.1136/bmj.i1753.
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Oocyte donation pregnancies and the risk of preeclampsia or gestational hypertension: a systematic review and metaanalysis.
采用妊娠筛查、生活方式及医学管理策略相结合的方法降低多囊卵巢综合征女性发生子痫前期的风险
J Clin Med. 2024 Mar 20;13(6):1774. doi: 10.3390/jcm13061774.
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Does the Oral Microbiome Play a Role in Hypertensive Pregnancies?口腔微生物组在高血压妊娠中起作用吗？
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A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.一项非靶向 LC-MS 分析显示，子痫前期婴儿脐带血浆中的肉碱前体和三甲基化化合物水平升高。
Sci Rep. 2018 Oct 2;8(1):14616. doi: 10.1038/s41598-018-32804-5.
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4
Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group.辅助生殖技术后妊娠高血压疾病的风险：来自CoNARTaS组的队列研究
Hum Reprod. 2015 Jul;30(7):1724-31. doi: 10.1093/humrep/dev090. Epub 2015 Apr 29.
5
Metabolically normal obese people are protected from adverse effects following weight gain.代谢正常的肥胖人群在体重增加后能免受不良影响。
J Clin Invest. 2015 Feb;125(2):787-95. doi: 10.1172/JCI78425. Epub 2015 Jan 2.
6
Risk factors differ between recurrent and incident preeclampsia: a hospital-based cohort study.复发性与新发先兆子痫的危险因素存在差异：一项基于医院的队列研究。
Ann Epidemiol. 2014 Dec;24(12):871-7e3. doi: 10.1016/j.annepidem.2014.10.003.
7
Combined impact of high body mass index and in vitro fertilization on preeclampsia risk: a hospital-based cohort study.高体重指数与体外受精对先兆子痫风险的综合影响：一项基于医院的队列研究。
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PLoS One. 2014 Mar 21;9(3):e91198. doi: 10.1371/journal.pone.0091198. eCollection 2014.