Sadeghi Masoud, Safaeian Leila, Ghazvini Mohammadreza Aghaye, Ramezani Mojtaba
Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Department of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Res Pharm Sci. 2017 Aug;12(4):299-306. doi: 10.4103/1735-5362.212047.
is a member of Amaryllidaceae family, which grows wildly in some western regions of Iran. Limited information is available about the pharmacological activities of this plant. The present study aimed to evaluate the fibrinolytic and antioxidant effects of hydroalcoholic extract of aerial parts. The antioxidant properties of the extract were evaluated by total phenolic content assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and ferric reducing antioxidant power (FRAP) assay. The studies included the determination of hydroperoxides level and FRAP value in serum samples of rats receiving i.p. injections of the plant extract for 21 days. The fibrinolytic activity of the extract was quantitatively evaluated by measuring the clot weight. antioxidant analysis exhibited the promising potential of DPPH scavenging and total antioxidant capacity of extract. In the analysis, extract reduced the serum hydroperoxides level and increased the serum total antioxidant capacity in rats. fibrinolytic assay also elucidated notable thrombolytic activity of the plant extract. The results of this study revealed the valuable antioxidant and fibrinolytic activities of extract. Further studies are needed for better evaluation of anticoagulant and thrombolytic activities of this plant and understanding its detailed mechanisms.
它是石蒜科的一员，在伊朗的一些西部地区野生生长。关于这种植物的药理活性的信息有限。本研究旨在评估地上部分水醇提取物的纤溶和抗氧化作用。通过总酚含量测定、1,1-二苯基-2-苦基肼（DPPH）清除活性和铁还原抗氧化能力（FRAP）测定来评估提取物的抗氧化性能。研究包括测定接受腹腔注射植物提取物21天的大鼠血清样本中的氢过氧化物水平和FRAP值。通过测量凝块重量对提取物的纤溶活性进行定量评估。抗氧化分析显示提取物具有良好的DPPH清除潜力和总抗氧化能力。在分析中，提取物降低了大鼠血清中的氢过氧化物水平并提高了血清总抗氧化能力。纤溶测定也阐明了植物提取物显著的溶栓活性。本研究结果揭示了提取物有价值的抗氧化和纤溶活性。需要进一步研究以更好地评估这种植物的抗凝和溶栓活性并了解其详细机制。
