• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用碳纳米纤维/金纳米颗粒复合丝网印刷碳电极对吡硫醇进行高灵敏度伏安测定。

Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode.

作者信息

Apetrei Irina Mirela, Apetrei Constantin

机构信息

Department of Pharmaceutical Sciences, Medical and Pharmaceutical Research Center, Faculty of Medicine and Pharmacy.

Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunarea de Jos" University of Galati, Galati, Romania.

出版信息

Int J Nanomedicine. 2017 Jul 21;12:5177-5188. doi: 10.2147/IJN.S138978. eCollection 2017.

DOI:10.2147/IJN.S138978
PMID:28860746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5560415/
Abstract

A novel and highly sensitive electrochemical method for the detection of pyritinol in pharmaceutical products and serum samples has been accomplished based on voltamperometric response of pyritinol in carbon nanofiber-gold nanoparticle (CNF-GNP)-modified screen-printed carbon electrode (SPCE). The electrochemical response of pyritinol to CNF-GNP-modified SPCE was studied by cyclic voltammetry and square-wave voltammetry (SWV). Under optimized working conditions, the novel sensor shows excellent voltamperometric response toward pyritinol. The SWV study shows significantly enhanced electrochemical response for pyritinol in CNF-GNP-modified SPCE providing high sensitivity to the novel sensor for pyritinol detection. The peak current for pyritinol is found to be linear with the concentration in the range 1.0×10-5.0×10 M with a detection limit of 6.23×10 M using SWV as the detection method. The viability of the new developed sensor for the analytical purposes was studied by performing experiments on various commercial pharmaceutical products and blood serum samples, which yielded adequate recoveries of pyritinol. The novel electrochemical sensor provides high sensitivity, enhanced selectivity, good reproducibility and practical applicability.

摘要

基于吡硫醇在碳纳米纤维-金纳米颗粒（CNF-GNP）修饰的丝网印刷碳电极（SPCE）上的伏安响应，已建立了一种用于检测药品和血清样品中吡硫醇的新型高灵敏度电化学方法。通过循环伏安法和方波伏安法（SWV）研究了吡硫醇对CNF-GNP修饰的SPCE的电化学响应。在优化的工作条件下，该新型传感器对吡硫醇表现出优异的伏安响应。SWV研究表明，CNF-GNP修饰的SPCE中吡硫醇的电化学响应显著增强，为吡硫醇检测的新型传感器提供了高灵敏度。以SWV作为检测方法，发现吡硫醇的峰值电流与浓度在1.0×10 - 5.0×10 M范围内呈线性关系，检测限为6.23×10 M。通过对各种商业药品和血清样品进行实验，研究了新开发传感器用于分析目的的可行性，结果显示吡硫醇的回收率良好。该新型电化学传感器具有高灵敏度、增强的选择性、良好的重现性和实际适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/4ccd3c5325ab/ijn-12-5177Fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/94c7883f2856/ijn-12-5177Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/661da7b14fa9/ijn-12-5177Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/a34d4ac650c8/ijn-12-5177Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/09801cba90bc/ijn-12-5177Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/a0ab3f6a8595/ijn-12-5177Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/ff77e721a894/ijn-12-5177Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/a998c2ee022b/ijn-12-5177Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/459628d974fb/ijn-12-5177Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/727b1572fa27/ijn-12-5177Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/c5c456045e76/ijn-12-5177Fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/4ccd3c5325ab/ijn-12-5177Fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/94c7883f2856/ijn-12-5177Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/661da7b14fa9/ijn-12-5177Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/a34d4ac650c8/ijn-12-5177Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/09801cba90bc/ijn-12-5177Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/a0ab3f6a8595/ijn-12-5177Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/ff77e721a894/ijn-12-5177Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/a998c2ee022b/ijn-12-5177Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/459628d974fb/ijn-12-5177Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/727b1572fa27/ijn-12-5177Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/c5c456045e76/ijn-12-5177Fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5eb/5560415/4ccd3c5325ab/ijn-12-5177Fig11.jpg

相似文献

1
Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode.使用碳纳米纤维/金纳米颗粒复合丝网印刷碳电极对吡硫醇进行高灵敏度伏安测定。
Int J Nanomedicine. 2017 Jul 21;12:5177-5188. doi: 10.2147/IJN.S138978. eCollection 2017.
2
Highly sensitive and selective determination of methylergometrine maleate using carbon nanofibers/silver nanoparticles composite modified carbon paste electrode.使用碳纳米纤维/银纳米颗粒复合修饰碳糊电极高灵敏选择性测定马来酸甲基麦角新碱
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:453-61. doi: 10.1016/j.msec.2016.06.077. Epub 2016 Jun 25.
3
A sensitive electrochemical sensor for rapid determination of methadone in biological fluids using carbon paste electrode modified with gold nanofilm.一种用于快速测定生物流体中美沙酮的灵敏电化学传感器，该传感器采用金纳米膜修饰的碳糊电极。
Talanta. 2014 Oct;128:203-10. doi: 10.1016/j.talanta.2014.03.003. Epub 2014 Mar 17.
4
A novel electrochemical platform based on carbon nanofibers and tri-metallic nanoparticles of gold, nickel and cobalt for the quantification of ethyl paraben.一种基于碳纳米纤维以及金、镍和钴的三金属纳米颗粒的新型电化学平台，用于对尼泊金乙酯进行定量分析。
Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:301-307. doi: 10.1016/j.msec.2016.11.080. Epub 2016 Nov 24.
5
Very sensitive electrochemical determination of diuron on glassy carbon electrode modified with reduced graphene oxide-gold nanoparticle-Nafion composite film.基于还原氧化石墨烯-金纳米粒子-全氟磺酸复合膜修饰玻碳电极的对草隆的高灵敏电化学测定
Ecotoxicol Environ Saf. 2017 Oct;144:171-177. doi: 10.1016/j.ecoenv.2017.06.030. Epub 2017 Jun 13.
6
Amperometric detection of catechol using tyrosinase modified electrodes enhanced by the layer-by-layer assembly of gold nanocubes and polyelectrolytes.基于层层组装金纳米立方体和聚电解质增强的酪氨酸酶修饰电极的安培检测儿茶酚。
Biosens Bioelectron. 2014 Nov 15;61:147-51. doi: 10.1016/j.bios.2014.05.011. Epub 2014 May 14.
7
A novel disposable electrochemical sensor for determination of carbamazepine based on Fe doped SnO2 nanoparticles modified screen-printed carbon electrode.一种基于铁掺杂二氧化锡纳米颗粒修饰丝网印刷碳电极的新型一次性电化学卡马西平测定传感器。
Mater Sci Eng C Mater Biol Appl. 2016 May;62:53-60. doi: 10.1016/j.msec.2016.01.027. Epub 2016 Jan 13.
8
Palladium nanoparticles decorated on activated fullerene modified screen printed carbon electrode for enhanced electrochemical sensing of dopamine.钯纳米粒子修饰在富勒烯修饰的丝网印刷碳电极上用于增强多巴胺的电化学传感。
J Colloid Interface Sci. 2015 Jun 15;448:251-6. doi: 10.1016/j.jcis.2015.02.013. Epub 2015 Feb 12.
9
Voltammetric detection of carbofuran determination using screen-printed carbon electrodes modified with gold nanoparticles and graphene oxide.使用金纳米粒子和氧化石墨烯修饰的丝网印刷碳电极对克百威进行伏安法检测。
Talanta. 2017 Dec 1;175:331-337. doi: 10.1016/j.talanta.2017.07.050. Epub 2017 Jul 18.
10
Electrooxidation behavior of warfarin in Fe3O4 nanoparticles modified carbon paste electrode and its determination in real samples.四氧化三铁纳米粒子修饰碳糊电极上华法林的电化学氧化行为及其在实际样品中的测定。
Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:235-42. doi: 10.1016/j.msec.2014.12.003. Epub 2014 Dec 4.

引用本文的文献

1
Carbon Nanofiber-Ionic Liquid Nanocomposite Modified Aptasensors Developed for Electrochemical Investigation of Interaction of Aptamer/Aptamer-Antisense Pair with Activated Protein C.碳纤维纳米纤维-离子液体纳米复合材料修饰适体传感器的电化学研究进展，用于研究适体/适体-反义寡核苷酸与活化蛋白 C 的相互作用。
Biosensors (Basel). 2023 Apr 4;13(4):458. doi: 10.3390/bios13040458.
2
Myoglobin- and Hydroxyapatite-Doped Carbon Nanofiber-Modified Electrodes for Electrochemistry and Electrocatalysis.用于电化学和电催化的肌红蛋白与羟基磷灰石掺杂碳纳米纤维修饰电极
ACS Omega. 2019 Sep 11;4(13):15653-15659. doi: 10.1021/acsomega.9b02151. eCollection 2019 Sep 24.
3

本文引用的文献

1
New Gold Nanostructures for Sensor Applications: A Review.用于传感器应用的新型金纳米结构：综述
Materials (Basel). 2014 Jul 17;7(7):5169-5201. doi: 10.3390/ma7075169.
2
Polyelectrolyte-graphene Nanocomposites for Biosensing Applications.用于生物传感应用的聚电解质-石墨烯纳米复合材料
Curr Org Chem. 2015 Sep;19(18):1819-1827. doi: 10.2174/1385272819666150526005557.
3
Highly sensitive and selective determination of methylergometrine maleate using carbon nanofibers/silver nanoparticles composite modified carbon paste electrode.
Multisensory System Used for the Analysis of the Water in the Lower Area of River Danube.
用于分析多瑙河下游区域水体的多感官系统。
Nanomaterials (Basel). 2019 Jun 17;9(6):891. doi: 10.3390/nano9060891.
4
Voltammetric sensing based on the use of advanced carbonaceous nanomaterials: a review.基于先进碳纳米材料的伏安传感：综述。
Mikrochim Acta. 2018 Jan 8;185(2):89. doi: 10.1007/s00604-017-2626-0.
使用碳纳米纤维/银纳米颗粒复合修饰碳糊电极高灵敏选择性测定马来酸甲基麦角新碱
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:453-61. doi: 10.1016/j.msec.2016.06.077. Epub 2016 Jun 25.
4
A Facile pH Controlled Citrate-Based Reduction Method for Gold Nanoparticle Synthesis at Room Temperature.一种在室温下通过简便的pH控制柠檬酸盐还原法合成金纳米粒子的方法。
Nanoscale Res Lett. 2016 Dec;11(1):362. doi: 10.1186/s11671-016-1576-5. Epub 2016 Aug 15.
5
Cognitive Interventions in Older Persons: Do They Change the Functioning of the Brain?针对老年人的认知干预措施：它们会改变大脑的功能吗？
Biomed Res Int. 2015;2015:438908. doi: 10.1155/2015/438908. Epub 2015 Oct 25.
6
A new microplatform based on titanium dioxide nanofibers/graphene oxide nanosheets nanocomposite modified screen printed carbon electrode for electrochemical determination of adenine in the presence of guanine.基于二氧化钛纳米纤维/氧化石墨烯纳米片纳米复合材料修饰的丝网印刷碳电极的新型微平台，用于在鸟嘌呤存在下电化学测定腺嘌呤。
Biosens Bioelectron. 2016 Mar 15;77:837-44. doi: 10.1016/j.bios.2015.10.055. Epub 2015 Oct 20.
7
Electrochemical oxidation of cysteine at a film gold modified carbon fiber microelectrode its application in a flow-through voltammetric sensor.金修饰碳纤维微电极上半胱氨酸的电化学氧化及其在流通伏安传感器中的应用。
Sensors (Basel). 2012;12(3):3562-77. doi: 10.3390/s120303562. Epub 2012 Mar 14.
8
Carbon paste electrodes made from different carbonaceous materials: application in the study of antioxidants.由不同碳质材料制成的碳糊电极：在抗氧化剂研究中的应用。
Sensors (Basel). 2011;11(2):1328-44. doi: 10.3390/s110201328. Epub 2011 Jan 25.
9
Stability-indicating chemometric methods for the determination of pyritinol dihydrochloride.稳定性指示化学计量学方法测定吡硫醇二盐酸盐。
Drug Test Anal. 2009 May;1(5):228-33. doi: 10.1002/dta.37.
10
Synthetic drugs with anti-ageing effects.具有抗衰老作用的合成药物。
Drug Discov Today. 2009 Sep;14(17-18):899-904. doi: 10.1016/j.drudis.2009.07.006. Epub 2009 Jul 26.