Hao Ji-Na, Xu Xiao-Yu, Lian Xiao, Zhang Chi, Yan Bing
China-Australia Joint Laboratory of Functional Molecules and Ordered Matters, School of Chemical Science and Engineering, Tongji University , Siping Road 1239, Shanghai 200092, China.
Inorg Chem. 2017 Sep 18;56(18):11176-11183. doi: 10.1021/acs.inorgchem.7b01549. Epub 2017 Sep 1.
A luminescent nanoprobe based on a lanthanide-transition heterometallic metal-organic framework (MOF) is first designed for specific detection of urinary thiodiglycolic acid (TDGA) which is the biomarker of carcinogenic vinyl chloride monomer (VCM) and represents the internal dose of human exposure to VCM. The nanoprobe demonstrates high selectivity to TDGA with about 27.5-fold luminescence enhancement. It also displays excellent sensitivity with a detection limit as low as 89 ng·mL and fast response to TDGA within 4 min, while refraining from the interference of other coexisting species in urine. Such good sensing performance enables the nanoprobe to practically monitor TDGA levels in human urine. Moreover, a portable urine dipstick based on the sensor is developed to conveniently evaluate individuals' intoxication degree of VCM. This fast, sensitive, and selective nanoprobe has promising potential to be a useful tool for point-of-care diagnosis of disease associated with VCM exposure.
首次设计了一种基于镧系-过渡异金属金属有机框架（MOF）的发光纳米探针，用于特异性检测尿中的硫代二甘醇酸（TDGA），TDGA是致癌氯乙烯单体（VCM）的生物标志物，代表人体接触VCM的内剂量。该纳米探针对TDGA表现出高选择性，发光增强约27.5倍。它还具有出色的灵敏度，检测限低至89 ng·mL，对TDGA在4分钟内快速响应，同时不受尿液中其他共存物质的干扰。如此良好的传感性能使该纳米探针能够实际监测人体尿液中的TDGA水平。此外，还开发了一种基于该传感器的便携式尿试纸，以方便地评估个体的VCM中毒程度。这种快速、灵敏且选择性的纳米探针有望成为用于即时诊断与VCM暴露相关疾病的有用工具。
