Department of Cancer Experiences, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Department of Psychiatry, University of Melbourne, Melbourne, VIC 3010, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC 3000, Australia.
J Psychiatr Res. 2017 Dec;95:156-178. doi: 10.1016/j.jpsychires.2017.08.004. Epub 2017 Aug 23.
Meditation is a popular form of stress management, argued to mediate stress reactivity. However, many studies in this field commonly fail to include an active control group. Given the frequency with which people are selecting meditation as a form of self-management, it is important to validate if the practice is effective in mediating stress-reactivity using well-controlled studies. Thus, we aimed to conduct a meta-analysis investigating the neurobiological effects of meditation, including focused attention, open monitoring and automatic self-transcending subtypes, compared to an active control, on markers of stress. In the current meta-analysis and systematic review, we included randomised controlled trials comparing meditation interventions compared to an active control on physiological markers of stress. Studied outcomes include cortisol, blood pressure, heart-rate, lipids and peripheral cytokine expression. Forty-five studies were included. All meditation subtypes reduced systolic blood pressure. Focused attention meditations also reduced cortisol and open monitoring meditations also reduced heart rate. When all meditation forms were analysed together, meditation reduced cortisol, C - reactive protein, blood pressure, heart rate, triglycerides and tumour necrosis factor-alpha. Overall, meditation practice leads to decreased physiological markers of stress in a range of populations.
冥想是一种流行的压力管理形式，被认为可以调节压力反应。然而，该领域的许多研究通常未能包括积极对照组。鉴于人们经常选择冥想作为自我管理的一种形式，重要的是要通过精心控制的研究来验证练习是否能有效地调节压力反应。因此，我们旨在进行一项荟萃分析，研究冥想（包括专注注意力、开放监控和自动自我超越亚型）与积极对照组相比，对压力标志物的神经生物学影响。在当前的荟萃分析和系统评价中，我们纳入了比较冥想干预与积极对照组对压力生理标志物的随机对照试验。研究结果包括皮质醇、血压、心率、血脂和外周细胞因子表达。共纳入 45 项研究。所有冥想亚型均降低收缩压。专注注意力冥想还降低了皮质醇，开放监控冥想还降低了心率。当所有冥想形式一起分析时，冥想降低了皮质醇、C 反应蛋白、血压、心率、甘油三酯和肿瘤坏死因子-α。总体而言，冥想练习在多种人群中降低了一系列压力的生理标志物。
