Woo Peak
Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine, New York, New York.
J Voice. 2018 Jul;32(4):492-498. doi: 10.1016/j.jvoice.2017.07.004. Epub 2017 Sep 1.
Hyaluronidase (HAase) injection into the vocal folds is an off-label use of an enzyme for liquefaction of hyaluronic acid (HA). HAase injection was performed in 14 cases in 13 patients. Office and operative injections of HAase were performed. The indications were five cases of overinjection of HA, six cases of Reinke edema and polypoid corditis, and three cases of acute vocal hemorrhage with early fusiform polyp formation. All the patients tolerated the HAase without complications. Significant voice improvements were noted between pre- and postinjection procedures as evaluated by a self-rating of voice by the Voice Handicap Index-10. A marked decrement in the mass on the side of the injection of HAase was noted in all groups successfully injected upon viewing by videostroboscopy. HAase prevented an additional operative phonosurgery in 10 patients. In conclusion, HAase injection can be used in the vocal folds with good effect in patients. The indications are polypoid corditis with overproduction of HA, acute vocal hemorrhage, and correction of iatrogenic HA overinjection.
向声带注射透明质酸酶（HAase）是一种将酶用于透明质酸（HA）液化的非适应证用法。对13例患者中的14例进行了HAase注射。进行了门诊和手术注射HAase。适应证包括5例HA过度注射、6例任克氏水肿和息肉样声带炎以及3例急性声带出血伴早期梭形息肉形成。所有患者均耐受HAase且无并发症。通过嗓音障碍指数-10进行嗓音自评评估，注射前后嗓音有显著改善。在所有成功注射HAase的组中，经频闪喉镜检查发现注射侧的肿物明显减小。HAase使10例患者避免了额外的手术性嗓音外科治疗。总之，HAase注射可用于声带，对患者有良好效果。适应证为HA产生过多的息肉样声带炎、急性声带出血以及医源性HA过度注射的矫正。
