Department of Otolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
Eur Arch Otorhinolaryngol. 2023 Jul;280(7):3323-3328. doi: 10.1007/s00405-023-07964-4. Epub 2023 Apr 11.
To investigate the effectiveness of in-office blue laser therapy on dyspnea in patients with type 3 Reinke's edema.
The medical records and video-recordings of patients with Reinke's edema type 3 who had undergone office-based blue laser therapy between March 2022 and January 2023 were reviewed. The primary outcome measures assessed before and after surgery were dyspnea severity, risk of obstructive sleep apnea (OSA), and disease regression. The severity of dyspnea was measured using the Dyspnea Severity Index (DSI), the risk of OSA was assessed using the STOP-BANG questionnaire, and disease regression was assessed by reviewing the laryngeal examination before and after surgery. The Voice Handicap Index-10 (VHI-10) was used as a secondary outcome measure.
A total of 10 patients were included. The mean age of the study population was 58.9 ± 4.2 years. The male-to-female ratio was 2:3. In total, 20 vocal fold lesions were treated among which 18 were reviewed. Eight lesions regressed completely and 10 partially. There was a statistically significant drop in the mean score of DSI after surgery (16.1 ± 10.2 pre-operatively vs 2.3 ± 2.3 post-operatively, p-value < 0.001). The mean STOP-BANG score decreased from 4.8 ± 1.47 to 3.1 ± 1.28 (p-value = 0.001). There was also a significant improvement in VHI-10 score (22.7 ± 7.0 vs 4.4 ± 5.6, p-value < 0.001).
Office-based blue laser therapy offers a safe and effective treatment for shortness of breath in patients with type 3 Reinke's edema.
探讨局麻下蓝激光治疗 3 型 Reinke 水肿患者呼吸困难的疗效。
回顾了 2022 年 3 月至 2023 年 1 月期间接受局麻下蓝激光治疗的 3 型 Reinke 水肿患者的病历和视频记录。手术前后评估的主要结局指标为呼吸困难严重程度、阻塞性睡眠呼吸暂停（OSA）风险和疾病消退。呼吸困难严重程度采用呼吸困难严重指数（DSI）进行评估，OSA 风险采用 STOP-BANG 问卷进行评估，疾病消退通过手术前后的喉镜检查进行评估。嗓音障碍指数-10（VHI-10）作为次要结局指标。
共纳入 10 例患者，平均年龄 58.9±4.2 岁，男女比例为 2:3。共治疗 20 个声带病变，其中 18 个进行了复查。8 个病变完全消退，10 个部分消退。手术后 DSI 平均评分显著下降（术前 16.1±10.2 分 vs 术后 2.3±2.3 分，p 值<0.001）。平均 STOP-BANG 评分从 4.8±1.47 降至 3.1±1.28（p 值=0.001）。VHI-10 评分也显著改善（22.7±7.0 分 vs 4.4±5.6 分，p 值<0.001）。
局麻下蓝激光治疗为 3 型 Reinke 水肿患者的呼吸困难提供了一种安全有效的治疗方法。
