Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.
Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea; School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Adv Drug Deliv Rev. 2018 Mar 1;127:35-45. doi: 10.1016/j.addr.2017.08.009. Epub 2017 Sep 1.
Transdermal drug delivery is a prospective drug delivery strategy to complement the limitations of conventional drug delivery systems including oral and injectable methods. This delivery route allows both convenient and painless drug delivery and a sustained release profile with reduced side effects. However, physiological barriers in the skin undermine the delivery efficiency of conventional patches, limiting drug candidates to small-molecules and lipophilic drugs. Recently, transdermal drug delivery technology has advanced from unsophisticated methods simply relying on natural diffusion to drug releasing systems that dynamically respond to external stimuli. Furthermore, physical barriers in the skin have been overcome using microneedles, and controlled delivery by wearable biosensors has been enabled ultimately. In this review, we classify the evolution of advanced drug delivery strategies based on generations and provide a comprehensive overview. Finally, the recent progress in advanced diagnosis and therapy through customized drug delivery systems based on real-time analysis of physiological cues is highlighted.
经皮给药是一种有前景的药物传递策略，可弥补包括口服和注射方法在内的传统药物传递系统的局限性。这种给药途径允许方便无痛地给药，并具有延长的释放曲线，减少副作用。然而，皮肤中的生理屏障削弱了传统贴片的输送效率，限制了候选药物只能是小分子和脂溶性药物。最近，经皮药物输送技术已经从简单地依赖于天然扩散的不成熟方法发展到能够动态响应外部刺激的药物释放系统。此外，已经使用微针克服了皮肤中的物理屏障，并最终实现了可穿戴生物传感器的控制输送。在这篇综述中，我们根据代际对先进药物输送策略的发展进行了分类，并提供了全面的概述。最后，强调了通过基于生理信号实时分析的定制药物输送系统进行先进诊断和治疗的最新进展。
