Stuelten Christina H
National Institutes of Health, National Cancer Institute, Laboratory of Cellular and Molecular Biology, 37 Convent Drive, Bethesda, MD 20892, USA.
J Clin Cell Immunol. 2017 Jun;8(3). doi: 10.4172/2155-9899.1000507. Epub 2017 May 29.
Migrating cells can influence the direction of their own migration by metabolizing chemoattractants present in their environment. This is illustrated by the dispersal of melanoma cells, which break down lysophosphatidic acid and generate a gradient with increasing concentrations of lysophosphatidic acid distant from the tumor. Melanoma cells can then disperse away from the tumor as they migrate in the self-generated lysophosphatidic acid gradient. Thus, dispersal of tumor cells during invasion of the surrounding stroma might be driven by chemotaxis of cells along self-generated chemoattractant gradients.
迁移细胞可通过代谢其周围环境中存在的趋化因子来影响自身迁移的方向。黑色素瘤细胞的扩散就说明了这一点，这些细胞分解溶血磷脂酸，并在远离肿瘤处生成溶血磷脂酸浓度不断增加的梯度。然后，黑色素瘤细胞在自身产生的溶血磷脂酸梯度中迁移时，便可从肿瘤处扩散开来。因此，肿瘤细胞在侵袭周围基质过程中的扩散可能是由细胞沿自身产生的趋化因子梯度进行的趋化作用所驱动的。
