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The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.SWI/SNF蛋白PBRM1抑制VHL缺失驱动的肾透明细胞癌。
Cell Rep. 2017 Mar 21;18(12):2893-2906. doi: 10.1016/j.celrep.2017.02.074.
2
Renal cell carcinoma.肾细胞癌。
Nat Rev Dis Primers. 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9.
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Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma.PBRM1 肿瘤抑制基因失活可扩增 VHL-/- 透明细胞肾细胞癌中的 HIF 反应。
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1027-1032. doi: 10.1073/pnas.1619726114. Epub 2017 Jan 12.
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Genomic Biomarkers of a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma.一项比较一线依维莫司和舒尼替尼治疗转移性肾细胞癌患者的随机试验的基因组生物标志物
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Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer.通过汇聚性基因组生物标志物发现克服肿瘤异质性带来的治疗障碍：肾癌的辫状癌河模型
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A clear picture of renal cell carcinoma.清晰呈现肾细胞癌。
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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.外显子组测序鉴定出肾癌中 SWI/SNF 复合物基因 PBRM1 的高频突变。
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人类透明细胞肾癌中的SWI/SNF肿瘤抑制基因PBRM1/BAF180

SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer.

作者信息

Nargund Amrita M, Osmanbeyoglu Hatice U, Cheng Emily H, Hsieh James J

机构信息

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

出版信息

Mol Cell Oncol. 2017 Jun 19;4(4):e1342747. doi: 10.1080/23723556.2017.1342747. eCollection 2017.

DOI:10.1080/23723556.2017.1342747
PMID:28868352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5540208/
Abstract

Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

摘要

染色质调节蛋白复合物中的突变主导了新的癌症基因格局。然而，对于单个畸变如何促成癌症形成却知之甚少。一种研究Pbrm1作用的新型Pbrm1肾癌小鼠模型，为SWI/SNF复合物如何作为肿瘤抑制因子发挥作用提供了急需的线索。