Yang Jing, Li Yong-Chao, Zhou Xiu-Ren, Xu Xin-Juan, Fu Qing-Yun, Liu Chang-Zhong
a School of Life Science and Technology , Henan Institute of Science and Technology , Hualan road, Xinxiang , P.R. China.
b School of Animal Science , Henan Institute of Science and Technology , Hualan road, Xinxiang , P.R. China.
Nat Prod Res. 2018 Sep;32(18):2238-2243. doi: 10.1080/14786419.2017.1371153. Epub 2017 Sep 4.
A new monoterpenoid, 7-acetyl-8,9-dihydroxy thymol (1), together with a known one 7,8-dihydroxy-9-buyryl thymol (2), were isolated from the dried flower buds of Lonicera japonica Thunb. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses. The potential antibacterial effects of these compounds on Staphylococcus aureus, Escherichia coli, Micrococcus luteus, and Bacillus cereus were evaluated. Interestingly, both compounds 1 and 2 exhibited significant antibacterial activities with IC values range from 27.64 ± 2.26 to 128.58 ± 13.26 μg/mL.
从忍冬科植物忍冬干燥花蕾中分离得到一个新的单萜类化合物7-乙酰基-8,9-二羟基百里香酚（1）和一个已知化合物7,8-二羟基-9-丁酰基百里香酚（2）。通过广泛的一维和二维核磁共振光谱数据分析阐明了它们的结构。评估了这些化合物对金黄色葡萄球菌、大肠杆菌、藤黄微球菌和蜡样芽孢杆菌的潜在抗菌作用。有趣的是，化合物1和2均表现出显著的抗菌活性，其IC值范围为27.64±2.26至128.58±13.26μg/mL。
