Ding Feng, Chen Seng, Zhang Wanshu, Tu Yufeng, Sun Yao
Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
Bioorg Med Chem. 2017 Oct 15;25(20):5179-5184. doi: 10.1016/j.bmc.2017.08.034. Epub 2017 Aug 22.
Molecular imaging can allow the non-invasive characterization and measurement of biological and biochemical processes at the molecular and cellular levels in living subjects. The imaging of specific molecular targets that are associated with cancers could allow for the earlier diagnosis and better treatment of diseases. Small molecule-based probes play prominent roles in biomedical research and have high clinical translation ability. Here, with an emphasis on small molecule-based probes, we review some recent developments in biomarkers, imaging techniques and multimodal imaging in molecular imaging and highlight the successful applications for molecular imaging of cancers.
分子成像能够在活体中对分子和细胞水平的生物及生化过程进行无创性表征和测量。对与癌症相关的特定分子靶点进行成像，有助于疾病的早期诊断和更好的治疗。基于小分子的探针在生物医学研究中发挥着重要作用，并且具有较高的临床转化能力。在此，我们重点关注基于小分子的探针，回顾分子成像中生物标志物、成像技术和多模态成像的一些最新进展，并强调其在癌症分子成像中的成功应用。
