[纳入RICARTO（托莱多心血管风险）研究的普通人群的特征与心血管事件：该研究纳入的前1500名个体的数据]
[Characteristics and cardiovascular events in a general population included in the RICARTO (RIesgo CARdiovascular TOledo) study: Data from the first 1,500 individuals included in the study].
作者信息
Rodríguez-Roca G C, Segura-Fragoso A, Villarín-Castro A, Alonso-Moreno F J, Rodríguez-Padial L, Rodríguez-García M L, Fernández-Conde J A, Rojas-Martelo G A, Menchén-Herreros A, Escobar-Cervantes C, Fernández-Martín J, Artigao-Rodenas L M, Carbayo-Herencia J A, Hernández-Moreno J
机构信息
Investigador Principal y Director del Proyecto RICARTO, Centro de Salud de La Puebla de Montalbán, La Puebla de Montalbán, Toledo, España.
Instituto de Ciencias de la Salud de Castilla-La Mancha, Consejería de Sanidad, Talavera de la Reina, Toledo, España.
出版信息
Semergen. 2018 Apr;44(3):180-191. doi: 10.1016/j.semerg.2017.07.002. Epub 2017 Aug 30.
INTRODUCTION
The aim of this study was to assess cardiovascular risk (CVR) by investigating the prevalence of CVR factors (CVRF), target organ damage (TOD), and cardiovascular disease (CVD) in general population of the health area of Toledo, Spain.
MATERIAL AND METHODS
Epidemiological and observational study that analysed a sample from the general population aged 18years or older, randomly selected from a database of health cards stratified by age and gender. Clinical history, physical examination, and complementary tests were performed. Total blood and serum samples were frozen at -85°C to evaluate genetic studies in the future. Standard statistical analysis was performed. CVR was assessed by the SCORE scale calibrated for the Spanish population, and the Framingham Heart Study scale.
RESULTS
A total of 1,500 individuals (mean age 49.1±15.8years, 55.6% women) were included. Prevalences: dyslipidaemia 56.9% (95% confidence interval [95% CI]: 54.3-59.4), hypertension 33.0% (95%CI: 30.6-35.4), diabetes mellitus 8.6% (95%CI: 7.17-10.1), smoking 24.2% (95%CI; 122.0-26.4), obesity 25.3% (95%CI; 23.1-27.5), and sedentary life-style 39.4% (95%CI; 36.9-41.8). No CVRF was reported in 21.1% of cases, and 18.6% had 3-5 CVRF. TOD: electrocardiographic left ventricular hypertrophy, 4.3%, peripheral artery disease, 10.1% (Doppler ultrasound), and 15.3% (oscillometric device), microalbuminuria, 4.3%, sub-clinical renal disease, 3.2%, and nephropathy in 3.8% (CKD-EPI). At least one CVD was reported in 9.2% of cases. A low CVR (SCORE) was present in 44.6% of individuals.
CONCLUSIONS
Dyslipidaemia was found in 60% of individuals, 40% had a sedentary life-style, 30% with hypertension, 20% smoked, 20% obesity, and almost 10% with diabetes. More than a half of individuals have a moderate-high-very high risk. The prevalence of TOD and CVD are significant.
引言
本研究旨在通过调查西班牙托莱多健康区域普通人群中心血管危险因素（CVRF）、靶器官损害（TOD）和心血管疾病（CVD）的患病率，评估心血管风险（CVR）。
材料与方法
进行了一项流行病学观察性研究，分析了从按年龄和性别分层的健康卡数据库中随机抽取的18岁及以上普通人群样本。进行了临床病史采集、体格检查和辅助检查。采集的全血和血清样本在-85°C下冷冻，以备将来进行基因研究。进行了标准的统计分析。通过针对西班牙人群校准的SCORE量表和弗雷明汉心脏研究量表评估CVR。
结果
共纳入1500名个体（平均年龄49.1±15.8岁，女性占55.6%）。患病率：血脂异常56.9%（95%置信区间[95%CI]：54.3 - 59.4），高血压33.0%（95%CI：30.6 - 35.4），糖尿病8.6%（95%CI：7.17 - 10.1），吸烟24.2%（95%CI；22.0 - 26.4），肥胖25.3%（95%CI；23.1 - 27.5），久坐生活方式39.4%（95%CI；36.9 - 41.8）。21.1%的病例未报告CVRF，18.6%的病例有3 - 5个CVRF。TOD：心电图左心室肥厚4.3%，外周动脉疾病10.1%（多普勒超声）和15.3%（示波测量装置），微量白蛋白尿4.3%，亚临床肾病3.2%，肾病3.8%（慢性肾脏病流行病学合作研究公式）。9.2%的病例报告至少有一种CVD。44.6%的个体存在低CVR（SCORE）。
结论
60%的个体存在血脂异常，40%有久坐生活方式，30%患有高血压，20%吸烟，20%肥胖，近10%患有糖尿病。超过一半的个体具有中度 -高度 - 极高风险。TOD和CVD的患病率显著。
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