Kumar Ankit, Verma Ajay Kumar, Kant Surya, Prakash Ved, Srivastava Anand, Srivastava Kanchan, Jain Amita, Srivastava Kishore K
Department of Pulmonary and Critical Care Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Lung India. 2017 Sep-Oct;34(5):430-433. doi: 10.4103/lungindia.lungindia_451_16.
Mycobacterium tuberculosis (MTB) Beijing strains are spread worldwide and are responsible for major outbreaks of tuberculosis (TB), sometimes spreading multidrug resistance (MDR).
The aim of this study was to explore clinical features associated with the infection with Beijing strains among MDR patients of pulmonary TB in Lucknow and surrounding areas.
It was a hospital-based epidemiological study. Our study population was selected from all the newly diagnosed patients attending outpatient department and admitted patients of Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India. Those isolates which were characterized to be MTB by morphological and molecular techniques were tested for their resistance against the first-line drugs; after which each patient's isolate was genotyped.
The results suggested that the presence of Beijing genotype in 31.78% of strains.
Our results predicted that genotypic patterns reveal a large diversity among the MTB Beijing strain population. Increasing frequency of Beijing strains demands further research to unravel the factors behind its propensity to prevail.
结核分枝杆菌（MTB）北京菌株在全球范围内传播，是结核病（TB）主要疫情的元凶，有时还会传播多重耐药性（MDR）。
本研究旨在探索印度北方邦勒克瑙及周边地区耐多药肺结核患者中与北京菌株感染相关的临床特征。
这是一项基于医院的流行病学研究。我们的研究对象选自印度北方邦勒克瑙乔治国王医科大学呼吸内科门诊所有新诊断患者及住院患者。通过形态学和分子技术鉴定为MTB的分离株进行一线药物耐药性检测；之后对每位患者的分离株进行基因分型。
结果表明31.78%的菌株存在北京基因型。
我们的结果预测，基因型模式显示MTB北京菌株群体存在很大差异。北京菌株频率的增加需要进一步研究以揭示其盛行倾向背后的因素。
