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肝片吸虫引起的人体肝片吸虫病:尼泊尔首例病例报告。

Human fascioliasis by Fasciola hepatica: the first case report in Nepal.

作者信息

Sah Ranjit, Khadka Shusila, Khadka Mohan, Gurubacharya Dipesh, Sherchand Jeevan Bahadur, Parajuli Keshab, Shah Niranjan Prasad, Kattel Hari Prasad, Pokharel Bharat Mani, Rijal Basista

机构信息

Department of Microbiology, Institute of Medicine, Tribhuvan University and Teaching Hospital (TUTH), Kathmandu, Nepal.

Department of Medicine (Gastroenterology), Institute of Medicine, Tribhuvan University and Teaching Hospital (TUTH), Kathmandu, Nepal.

出版信息

BMC Res Notes. 2017 Sep 5;10(1):439. doi: 10.1186/s13104-017-2761-z.

Abstract

BACKGROUND

Fascioliasis is a zoonotic disease caused by Fasciola species. Patient may be asymptomatic or presents with jaundice and biliary colic or right hypochondriac pain due to bile duct obstruction with gastrointestinal symptoms.

CASE PRESENTATION

We report a case of human fascioliasis in a 45 years old female presented to Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal on August, 2015 with fever, right hypochondriac pain, jaundice and occasional vomiting with anorexia for 4 months whose alkaline phosphatase was elevated and peripheral blood smear revealed eosinophilia. The patient also gives the history of consumption of water-cress. Endoscopic Retrograde Cholagiopancretography (ERCP) showed the presence of a flat worm resembling Fasciola hepatica and stool routine examination revealed ova of F. hepatica. The patient was treated with nitazoxanide by which she got improved. Repeat stool examination 2 weeks after treatment revealed no ova of F. hepatica.

CONCLUSIONS

Patient with fascioliasis can be simply diagnosed with stool routine microscopy and treated with nitazoxanide. So patient with right hypochondriac pain, sign and symptoms of obstructive jaundice, eosinophilia and history of water-cress consumption should be suspected for fascioliasis and investigated and treated accordingly.

摘要

背景

肝片吸虫病是一种由肝片吸虫属引起的人畜共患病。患者可能无症状,或因胆管阻塞出现黄疸、胆绞痛或右季肋部疼痛,并伴有胃肠道症状。

病例报告

我们报告一例人类肝片吸虫病病例,患者为一名45岁女性,于2015年8月就诊于尼泊尔加德满都的特里布万大学教学医院(TUTH),发热、右季肋部疼痛、黄疸并伴有偶尔呕吐及食欲不振4个月,碱性磷酸酶升高,外周血涂片显示嗜酸性粒细胞增多。患者有食用水田芥的病史。内镜逆行胰胆管造影(ERCP)显示存在一条类似肝片吸虫的扁平虫,粪便常规检查发现肝片吸虫卵。患者接受硝唑尼特治疗后病情好转。治疗2周后复查粪便检查未发现肝片吸虫卵。

结论

肝片吸虫病患者可通过粪便常规显微镜检查简单诊断,并使用硝唑尼特治疗。因此,对于有右季肋部疼痛、梗阻性黄疸体征和症状、嗜酸性粒细胞增多以及食用水田芥病史的患者,应怀疑为肝片吸虫病并进行相应的检查和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/5583974/044291b4fa90/13104_2017_2761_Fig1_HTML.jpg

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