Suzuki K
Department of Pediatrics,Tokai University School of Medicine,Isehara,Japan.
J Dev Orig Health Dis. 2018 Jun;9(3):266-269. doi: 10.1017/S2040174417000691. Epub 2017 Sep 5.
Since its debut in a ground-breaking report by Barker and Osmond in 1986, the concept of the Developmental Origins of Health and Disease (DOHaD) has been further developed in several aspects. Its methodology and conclusions relating to proposed origins and outcomes of early life events have been developing and spreading internationally. Indeed, the DOHaD concept now seems to have influenced many fields of research. This article aims to briefly review why the DOHaD concept is important in biomedical science, how it has developed, is currently developing, and how it should develop in future.
自1986年巴克和奥斯蒙德发表具有开创性意义的报告首次提出以来，健康与疾病的发育起源（DOHaD）概念在多个方面得到了进一步发展。其与早期生活事件的假定起源和结果相关的方法和结论在国际上不断发展和传播。事实上，DOHaD概念如今似乎已经影响到了许多研究领域。本文旨在简要回顾DOHaD概念在生物医学科学中为何重要，它是如何发展的、目前的发展状况以及未来应如何发展。
