Smell & Taste Clinic, Department of ORL, TU Dresden, Dresden, Germany; UCL Ear Institute, London, UK; Centre for the Study of the Senses, School of Advanced Study, London, UK.
Smell & Taste Clinic, Department of ORL, TU Dresden, Dresden, Germany.
Neuroscience. 2017 Nov 5;363:26-33. doi: 10.1016/j.neuroscience.2017.08.046. Epub 2017 Sep 1.
Use of chemosensory event-related potentials (ERPs) is limited by relatively poor signal-to-noise ratios (SNRs). We hypothesized that by reducing the standard inter-stimulus interval (ISI), the increased number of trial repetitions possible may increase SNR. In order to further investigate this, we performed the largest study to date assessing chemosensory ERP using short and long ISIs in 101 participants of varying olfactory function. Using rose odor (phenylethylalcohol, PEA) as a relatively selective olfactory stimulant, we found no significant difference in the proportion of individuals in whom ERPs were recorded using short or long ISIs. This was true in normosmic, hyposmic and functionally anosmic individuals. We also demonstrated significantly increased SNR using short PEA-ISIs, in the normosmic and functionally anosmic groups. Comparing between groups of different olfactory function, hyposmic patients achieved faster onsets and greater amplitudes than normosmics under the PEA-10s protocol. This could be due to increased stimulus attendance, but requires confirmation with further research.
使用化学感觉事件相关电位（ERPs）受到相对较差的信噪比（SNR）的限制。我们假设通过减少标准的刺激间间隔（ISI），可以增加可能的试验重复次数，从而提高 SNR。为了进一步研究这一点，我们进行了迄今为止最大的研究，评估了 101 名具有不同嗅觉功能的参与者使用短和长 ISI 的化学感觉 ERP。使用玫瑰香味（苯乙醇，PEA）作为相对选择性的嗅觉刺激物，我们发现使用短或长 ISI 记录 ERPs 的个体比例没有显著差异。在嗅觉正常、嗅觉减退和功能性失嗅的个体中都是如此。我们还证明了使用短 PEA-ISIs 可以显著提高 SNR，在嗅觉正常和功能性失嗅的组中。在不同嗅觉功能的组之间进行比较，在 PEA-10s 方案下，嗅觉减退患者的起始时间比嗅觉正常者更快，幅度更大。这可能是由于刺激注意力的增加，但需要进一步的研究来证实。
