Takahashi H, Nakashima S, Kumanishi T, Ikuta F
Acta Neuropathol. 1987;73(3):227-32. doi: 10.1007/BF00686615.
An immunohistochemical study on tyrosine hydroxylase (TH), a rate-limiting enzyme in the catecholamine synthesizing pathway, was made on three craniocervical region paragangliomas, two of which showed metastases to the cervical lymph nodes. In all of the original tumors, the majority of tumor cells showed positive immunostaining for TH of variable intensity in their cytoplasm regardless of their cytological features such as cellular and nuclear pleomorphism. The finding suggests that most tumor cells are capable of production of catecholamines and are derived from chief cells in the normal paraganglia. In cervical lymph nodes, however, no positive immunostaining for TH was observed in metastatic tumor cells, in contrast with the findings in the original tumors. The absence of TH immunoreactivity in metastatic tumor cells appears to be noteworthy in considering their malignant potential. Application of the TH immunohistochemistry to further cases appears important for the better understanding of this neoplasm, a catecholamine-producing tumor.
对三例颅颈区副神经节瘤进行了免疫组化研究，其中两例出现颈部淋巴结转移。酪氨酸羟化酶（TH）是儿茶酚胺合成途径中的限速酶。在所有原发肿瘤中，无论肿瘤细胞的细胞学特征如何，如细胞和核多形性，大多数肿瘤细胞的细胞质中TH免疫染色呈不同强度阳性。这一发现表明，大多数肿瘤细胞能够产生儿茶酚胺，且来源于正常副神经节中的主细胞。然而，与原发肿瘤的结果相反，在颈部淋巴结的转移瘤细胞中未观察到TH免疫染色阳性。考虑到转移瘤细胞的恶性潜能，其缺乏TH免疫反应性似乎值得关注。将TH免疫组化应用于更多病例，对于更好地理解这种产生儿茶酚胺的肿瘤似乎很重要。
