Ribeiro Daniel Araki, Cardoso Caroline Margonato, Yujra Veronica Quispe, DE Barros Viana Milena, Aguiar Odair, Pisani Luciana Pellegrini, Oshima Celina Tizuko Fujiyama
Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Sao Paulo, Brazil
Department of Pathology, Federal University of Sao Paulo, UNIFESP, Sao Paulo, Brazil.
Anticancer Res. 2017 Sep;37(9):4767-4777. doi: 10.21873/anticanres.11883.
Apoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features different from other cellular mechanisms of death such as necrosis. In the last years, apoptosis has been extensively studied in the scientific literature, because it has been established that apoptosis plays a crucial role following the time course of chronic degenerative diseases, such as cancer. Thus, several researchers have strugged to detect what chemical agents are able to inter fere with the apoptotic process. Thus, the purpose of this literature review is to assess if fluoride induces apoptosis in mammalian cells using in vivo and in vitro test systems. Certain mammalian cell types such as oral cells, blood and brain were exetensively investigated; the results showed that fluoride is able to induce apoptosis in both intrinsinc and extrinsic pathways. Moreover, other cells types have been poorly investigated such as bone, kidney and reproductive cells with conflicting results so far. Therefore, this area needs further investigation for the safety of human populations exposed to fluoride in a chronic way, as for example in developing countries.
细胞凋亡是一种由基因编程的细胞死亡过程，是细胞衰老的不可逆过程，其特征不同于其他细胞死亡机制，如坏死。近年来，细胞凋亡在科学文献中得到了广泛研究，因为已经确定细胞凋亡在诸如癌症等慢性退行性疾病的病程中起着关键作用。因此，一些研究人员一直在努力检测哪些化学物质能够干扰细胞凋亡过程。因此，本文献综述的目的是使用体内和体外测试系统评估氟化物是否能诱导哺乳动物细胞凋亡。某些哺乳动物细胞类型，如口腔细胞、血液和大脑细胞，已得到广泛研究；结果表明，氟化物能够在内在和外在途径中诱导细胞凋亡。此外，其他细胞类型，如骨细胞、肾细胞和生殖细胞，研究较少，目前结果相互矛盾。因此，对于长期接触氟化物的人群，如发展中国家的人群，该领域的安全性需要进一步研究。
