School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Nat Commun. 2017 Sep 4;8(1):426. doi: 10.1038/s41467-017-00465-z.
Crystallization-driven self-assembly of diblock copolymers into cylindrical micelles of controlled length has emerged as a promising approach to the fabrication of functional nanoscale objects with high shape anisotropy. Here we show the preparation of a series of crystallizable diblock copolymers with appropriate wettability and chemical reactivity, and demonstrate their self-assembly into size-specific cylindrical micelle building blocks for the hierarchical construction of mechanically robust colloidosomes with a range of membrane textures, surface chemistries and optical properties. The colloidosomes can be structurally elaborated post assembly by in situ epitaxial elongation of the membrane building blocks to produce microcapsules covered in a chemically distinct, dense network of hair-like outgrowths. Our approach provides a route to hierarchically ordered colloidosomes that retain the intrinsic growth activity of their constituent building blocks to permit biofunctionalization, and have potential applications in areas such as biomimetic encapsulation, drug delivery, catalysis and biosensing.Functional nanoscale objects can be prepared via crystallization-driven self-assembly of diblock copolymers. Here the authors show the self-assembly of crystalline block copolymers into size-specific cylindrical micelles for the hierarchical construction of mechanically robust colloidosomes with a range of membrane textures.
通过两亲嵌段共聚物的结晶驱动自组装可以制备具有高形状各向异性的功能性纳米级物体。在这里，我们展示了一系列具有适当润湿性和化学反应性的结晶性两亲嵌段共聚物的制备，并证明了它们可以自组装成具有特定尺寸的圆柱形胶束作为构建基元，用于分级构建具有多种膜质地、表面化学和光学性质的机械坚固的胶体囊。胶体囊可以通过在组装后对膜构建基元进行原位外延伸长来进行结构修饰，从而在具有化学上不同的密集毛发状突起的网络覆盖的微胶囊。我们的方法提供了一种制备具有分级有序的胶体囊的途径，这些胶体囊保留了其组成构建基元的固有生长活性，允许进行生物功能化，并在仿生封装、药物传递、催化和生物传感等领域具有潜在应用。
