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核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

…介导的金和银纳米颗粒的合成：优化、表征及对恶性细胞和细菌细胞的抑制效率

..‑Mediated Synthesis of Gold and Silver Nanoparticles: Optimization, Characterization, and Inhibitory Efficiency Against Malignant and Bacterial Cells.

作者信息

Hamida Reham Samir, Ali Mohamed Abdelaal, Momenah Maha Abdullah, Alkhateeb Mariam Abdulaziz, Alfassam Haifa Essa, Bin-Meferij Mashael Mohammed

机构信息

Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan.

Department of Biological Sciences, Graduate School of Science, The University of Osaka, Osaka 560-0043, Japan.

出版信息

ACS Omega. 2025 Jul 25;10(31):34123-34141. doi: 10.1021/acsomega.3c10438. eCollection 2025 Aug 12.

DOI:10.1021/acsomega.3c10438
PMID:40821574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12355241/
Abstract

Metallic nanoparticles (NPs) are effective in various biological processes. In particular, gold (Au) and silver (Ag) NPs have unique properties that make them ideal candidates for therapeutic applications. This study aimed to explore the potential of a new isolate, .., for the extracellular synthesis of Au- and AgNPs and to evaluate their anticancer and antibacterial activities. The cyanobacteria were isolated and morphologically and genetically identified; their chemical constituents were detected using LC-QTOF-MS. .. mediated the syntheses of Au and Ag NPs using two methods (cell-free media and cell biomass extracts). The syntheses were optimized by controlling various parameters, such as the concentration, temperature, illumination, and pH, to obtain small and stable LC@AgNPs, LC@AgNPs, LC@AuNPs, and LC@AuNPs. The NPs were physicochemically characterized, and their antibacterial and anticancer activities were studied. Au and Ag NPs were successfully synthesized by .. suggesting that their peptides, amino acids, polysaccharides, and fatty acids were the main reagent-mediated synthesis. LC@AgNPs, LC@AgNPs, LC@AuNPs, and LC@AuNPs are small and negatively charged, enabling them to be used as antibacterial and anticancer agents. .. represented a novel source for synthesizing Au and Ag NPs, and these NPs have been demonstrated to be effective therapeutic agents.

摘要

金属纳米颗粒（NPs）在各种生物过程中都很有效。特别是，金（Au）和银（Ag）纳米颗粒具有独特的性质，使其成为治疗应用的理想候选者。本研究旨在探索一种新分离物……用于细胞外合成金纳米颗粒和银纳米颗粒的潜力，并评估它们的抗癌和抗菌活性。分离出蓝藻并进行形态学和遗传学鉴定；使用液相色谱-四极杆飞行时间质谱（LC-QTOF-MS）检测其化学成分。……使用两种方法（无细胞培养基和细胞生物质提取物）介导金纳米颗粒和银纳米颗粒的合成。通过控制各种参数，如浓度、温度、光照和pH值，对合成过程进行优化，以获得小尺寸且稳定的LC@AgNPs、LC@AgNPs、LC@AuNPs和LC@AuNPs。对纳米颗粒进行了物理化学表征，并研究了它们的抗菌和抗癌活性。……成功合成了金纳米颗粒和银纳米颗粒，表明其肽、氨基酸、多糖和脂肪酸是主要的试剂介导合成成分。LC@AgNPs、LC@AgNPs、LC@AuNPs和LC@AuNPs尺寸小且带负电荷，使其能够用作抗菌和抗癌剂。……代表了一种合成金纳米颗粒和银纳米颗粒的新来源，并且这些纳米颗粒已被证明是有效的治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4309/12355241/62f37eb1ffa9/ao3c10438_0012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4309/12355241/1605be3f8b61/ao3c10438_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4309/12355241/8ef82062a084/ao3c10438_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4309/12355241/b0c1826f2bda/ao3c10438_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4309/12355241/17cd8489692e/ao3c10438_0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4309/12355241/62f37eb1ffa9/ao3c10438_0012.jpg

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本文引用的文献

[1]
Harnessing Strain CCAP 6006/5 for the Eco-Friendly Synthesis of Silver Nanoparticles: Insights into the Anticancer and Antibacterial Efficacy.

Molecules. 2024-8-7

[2]
Phyco-synthesis of silver nanoparticles by environmentally safe approach and their applications.

Sci Rep. 2024-4-26

[3]
Antitumor effect of algae silver nanoparticles on human triple negative breast cancer cells.

Biomed Pharmacother. 2023-12

[4]
-Mediated Synthesis of Silver Nanoparticles: Optimization, Characterization, and Anticancer and Antibacterial Potentials.

ACS Omega. 2023-8-1

[5]
Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles.

Front Microbiol. 2023-7-24

[6]
Investigation of in vitro antimicrobial, antioxidant and antiproliferative activities of Nostoc calcicola biosynthesized gold nanoparticles.

Bioprocess Biosyst Eng. 2023-9

[7]
Recent progress of gold nanostructures and their applications.

Phys Chem Chem Phys. 2023-7-19

[8]
Green Biosynthesis of Silver Nanoparticles Using Aqueous Extracts of and Their Anti-Inflammatory Effects.

ACS Appl Mater Interfaces. 2023-3-7

[9]
One-Step Phytofabrication Method of Silver and Gold Nanoparticles Using for Anticancer, Antimicrobial, and Antioxidant Activities.

Pharmaceutics. 2023-2-4

[10]
Antibacterial Properties of Gold Nanoparticles in the Modification of Medical Implants: A Systematic Review.

Pharmaceutics. 2022-11-30

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