认知障碍程度不同，复杂多病共病负担增加。
Increasing Burden of Complex Multimorbidity Across Gradients of Cognitive Impairment.
机构信息
1 Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
2 Population Health and Outcomes Research Core, Clinical and Translational Science Collaborative, Cleveland, OH, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2017 Nov;32(7):408-417. doi: 10.1177/1533317517726388. Epub 2017 Sep 5.
INTRODUCTION
This study evaluates the burden of multimorbidity (MM) across gradients of cognitive impairment (CI).
METHODS
Using data from the 2010 Health and Retirement Study, we identified individuals with no CI, mild CI, and moderate/severe CI. In addition, we adopted an expansive definition of complex MM by accounting for the occurrence and co-occurrence of chronic conditions, functional limitations, and geriatric syndromes.
RESULTS
In a sample of 18 913 participants (weighted n = 87.5 million), 1.93% and 1.84% presented with mild and moderate/severe CI, respectively. The prevalence of most conditions constituting complex MM increased markedly across the spectrum of CI. Further, the percentage of individuals presenting with 10 or more conditions was 19.9%, 39.3%, and 71.3% among those with no CI, mild CI, and moderate/severe CI, respectively.
DISCUSSION
Greater CI is strongly associated with increased burden of complex MM. Detailed characterization of MM across CI gradients will help identify opportunities for health care improvement.
简介
本研究评估了认知障碍（CI）程度不同的情况下多种合并症（MM）的负担。
方法
我们使用了 2010 年健康与退休研究的数据，确定了没有 CI、轻度 CI 和中度/重度 CI 的个体。此外，我们通过考虑慢性疾病、功能限制和老年综合征的发生和共存，采用了广泛的复杂 MM 定义。
结果
在 18913 名参与者的样本中（加权 n=8750 万），分别有 1.93%和 1.84%的人患有轻度和中度/重度 CI。构成复杂 MM 的大多数疾病的患病率在 CI 谱中明显增加。此外，在没有 CI、轻度 CI 和中度/重度 CI 的个体中，分别有 19.9%、39.3%和 71.3%的人出现了 10 种或更多疾病。
讨论
CI 程度越大，与复杂 MM 的负担增加呈强相关。对 CI 梯度上 MM 的详细特征描述将有助于确定改善医疗保健的机会。
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