健康角膜的角膜密度测量及其与内皮形态测量的相关性。

Corneal Densitometry in Healthy Corneas and Its Correlation With Endothelial Morphometry.

作者信息

Tekin Kemal, Sekeroglu Mehmet Ali, Kiziltoprak Hasan, Yilmazbas Pelin

机构信息

Ophthalmology Department, Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

出版信息

Cornea. 2017 Nov;36(11):1336-1342. doi: 10.1097/ICO.0000000000001363.

DOI:10.1097/ICO.0000000000001363

PMID:28872516

Abstract

PURPOSE

To evaluate the correlations between corneal endothelial cell properties and corneal densitometry values and to investigate whether corneal densitometry may be used as an indicator of the health of corneal endothelium.

METHODS

Two hundred fifty-three eyes were analyzed in this prospective cross-sectional study. Corneal densitometry was measured with densitometry software of Pentacam HR-Scheimpflug corneal topography over a 12-mm diameter of the cornea. Furthermore, corneal endothelial cell properties including cell density (CD), average cell area, SD of the cell area, coefficient of variation (CV) of the cell area, maximum cell area, minimum cell area, and percentage of hexagonal cells (HEX) were measured by a specular microscope. The correlations were calculated using Pearson correlation tests.

RESULTS

The average cell area, SD, maximum cell area, and minimum cell area values were not statistically significantly correlated with the corneal densitometry values in any layer or concentric annulus. CD, CV, and HEX were statistically significantly correlated with the corneal densitometry values in all layers and concentric annuli (P < 0.05 for each one). Moreover, CD and HEX were inversely and moderately correlated with total corneal densitometry (r = -0.403, P < 0.001, and r = -0.327, P < 0.001, respectively), whereas the CV was positively and moderately correlated with total corneal densitometry (r = 0.349, P < 0.001).

CONCLUSIONS

Corneal densitometry might have potential to be used as an indicator of the health of corneal endothelium in the future.

摘要

目的

评估角膜内皮细胞特性与角膜密度测量值之间的相关性，并研究角膜密度测量是否可作为角膜内皮健康的指标。

方法

在这项前瞻性横断面研究中分析了253只眼睛。使用Pentacam HR-Scheimpflug角膜地形图的密度测量软件在直径12毫米的角膜上测量角膜密度。此外，通过镜面显微镜测量角膜内皮细胞特性，包括细胞密度（CD）、平均细胞面积、细胞面积标准差、细胞面积变异系数（CV）、最大细胞面积、最小细胞面积和六边形细胞百分比（HEX）。使用Pearson相关性检验计算相关性。

结果

在任何层或同心环中，平均细胞面积、标准差、最大细胞面积和最小细胞面积值与角膜密度测量值均无统计学显著相关性。CD、CV和HEX与所有层和同心环中的角膜密度测量值均有统计学显著相关性（每项P<0.05）。此外，CD和HEX与总角膜密度呈中度负相关（r=-0.403，P<0.001和r=-0.327，P<0.001），而CV与总角膜密度呈中度正相关（r=0.349，P<0.001）。