Ulucanlar Eye Education and Research Hospital, University of Health Sciences, Ulucanlar Caddesi No:59, 06240, Altindag Ankara, Turkey.
Int Ophthalmol. 2024 Feb 12;44(1):64. doi: 10.1007/s10792-024-03004-0.
To compare the corneal densitometry (CD) in pediatric cases with glaucoma following childhood cataract surgery and juvenile open-angle glaucoma (JOAG).
This prospective comparative study involved 13 eyes with JOAG, 12 eyes with pseudophakic glaucoma, 13 eyes with aphakic glaucoma, and 15 control subjects. Pentacam HR Scheimpflug corneal topography was employed to evaluate corneal thickness (CCT) and CD values.
The mean intraocular pressure (IOP) and CCT were significantly higher in aphakic glaucoma cases than the other groups (p = 0.001). In aphakic eyes, the mean CD values were higher in most of the anterior, center, and posterior layers of 0-2 mm, 2-6 mm, 6-10 mm, and total zones (p < 0.001 for all). In pseudophakic eyes, the mean CD values were statistically similar with that of aphakic eyes and higher than that of JOAG and control eyes in all layers of 0-2 mm zone and in anterior layer of 10-12 mm and anterior and total layers of 2-6 mm zones (p < 0.05 for all). The CD values demonstrated significant correlations with CCT values in both aphakic and pseudophakic eyes. However, a significant correlation of CD values with IOP was only demonstrated in aphakic eyes (p = 0.01 for all).
The probable effects of childhood cataract surgery especially aphakia might cause corneal backscatter of light and increased CD in all layers in all zones of the cornea. Increased CD values and its correlation with CCT and IOP in aphakic glaucoma eyes may be of importance in clinical management.
比较儿童白内障术后青光眼和青少年开角型青光眼（JOAG）患儿的角膜密度（CD）。
本前瞻性对照研究纳入 13 只 JOAG 眼、12 只后发性白内障青光眼眼、13 只无晶状体眼青光眼眼和 15 只对照眼。使用 Pentacam HR Scheimpflug 角膜地形图评估角膜厚度（CCT）和 CD 值。
无晶状体青光眼组的平均眼压（IOP）和 CCT 显著高于其他组（p=0.001）。在无晶状体眼中，0-2mm、2-6mm、6-10mm 和全层的大部分前层、中央层和后层的平均 CD 值均较高（p<0.001）。在人工晶状体眼，CD 值在各层与无晶状体眼相似，在 0-2mm 层和 10-12mm 前层以及 2-6mm 前层和全层高于 JOAG 眼和对照组（p<0.05）。CD 值与无晶状体眼和人工晶状体眼的 CCT 值均呈显著相关。然而，只有在无晶状体眼中，CD 值与 IOP 呈显著相关（p<0.05）。
儿童白内障手术的可能影响，特别是无晶状体，可能导致角膜所有层的光后向散射增加和 CD 增加。无晶状体青光眼眼 CD 值增加及其与 CCT 和 IOP 的相关性可能对临床管理具有重要意义。
