1 State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
2 Department of Neurology, Shenzhen People' s Hospital, Second Clinical College, Jinan University, Guangzhou, China.
Neuroscientist. 2018 Oct;24(5):526-539. doi: 10.1177/1073858417728459. Epub 2017 Sep 5.
Given their neuroanatomical similarities to humans and their ability to perform complex behaviors, the nonhuman primate has been an important model for understanding complex systems such as sensory processing, motor control, social interaction, and nervous system disorders. Optogenetics offers cell-type specific neural control with millisecond precision, making it a powerful neural modulation technique. Combining optogenetics with the nonhuman primate model promises to lead to significant advances in both basic and applied research. In the past few years, optogenetics has made considerable progress in the nonhuman primate. Here, we systematically review the current state-of-art of optogenetics in the nonhuman primate with an emphasis on behavioral manipulation. Given its recent successes, we believe that the progress in the nonhuman primate will boost the translation of optogenetics to clinical applications in the near future.
鉴于非人灵长类动物在神经解剖学上与人类相似，并且能够表现出复杂的行为，因此非人灵长类动物已成为理解复杂系统（如感觉处理、运动控制、社交互动和神经系统疾病）的重要模型。光遗传学提供了具有毫秒级精度的细胞类型特异性神经控制，是一种强大的神经调节技术。将光遗传学与非人类灵长类动物模型相结合，有望在基础研究和应用研究方面取得重大进展。在过去的几年中，光遗传学在非人类灵长类动物中取得了相当大的进展。在这里，我们系统地回顾了光遗传学在非人类灵长类动物中的最新进展，重点介绍了行为操作。鉴于其最近的成功，我们相信非人灵长类动物的进展将在不久的将来推动光遗传学向临床应用的转化。
