School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).
Med Sci Monit. 2020 Apr 5;26:e919815. doi: 10.12659/MSM.919815.
BACKGROUND Fructus aurantii is a flavonoid derived from Citrus aurantium (bitter orange) that is used in traditional Chinese medicine (TCM) to treat gastric motility disorders. This study aimed to investigate the effects of low-dose and high-dose decoctions of Fructus aurantii in a rat model of functional dyspepsia (FD). MATERIAL AND METHODS Sprague-Dawley rats (n=90) were divided into nine study groups: the control group, the FD model group, the domperidone-treated (Domp) group, the low-dose raw Fructus aurantii (FA-L) group, the high-dose raw Fructus aurantii (FA-H) group, the low-dose Fructus aurantii with stir-fried wheat bran (Bran-L) group, the high-dose Fructus aurantii with stir-fried wheat bran (Bran-H) group, the low-dose Fructus aurantii with stir-fried wheat bran and honey (Honey-L) group, and the high-dose Fructus aurantii with stir-fried wheat bran and honey (Honey-H) group. The FD rat model was established by semi-starvation, followed by tail damping, stimulation, and forced exercise with fatigue. Change in weight, rate of gastric emptying and intestinal propulsion, and serum levels of leptin, motilin, vasoactive intestinal peptide (VIP), gastrin, calcitonin gene-related peptide (CGRP), ghrelin, and cholecystokinin were compared between the groups. RESULTS In the FD model group, weight, rate of gastric emptying and intestinal propulsion significantly decreased, the expression of leptin, VIP and CGRP increased, and expression of motilin, gastrin, ghrelin, and cholecystokinin significantly decreased. Treatment with low-dose Fructus aurantii with stir-fried wheat bran significantly reversed these effects. CONCLUSIONS In the rat model of FD, low-dose Fructus aurantii with stir-fried wheat bran increased gastrointestinal motility and gastrointestinal hormone levels.
酸橙果实是一种来源于酸橙（苦橙）的类黄酮，在中国传统医学（TCM）中用于治疗胃动力障碍。本研究旨在探讨低剂量和高剂量酸橙汤在功能性消化不良（FD）大鼠模型中的作用。
将 Sprague-Dawley 大鼠（n=90）分为 9 个研究组：对照组、FD 模型组、多潘立酮治疗（Domp）组、低剂量生酸橙（FA-L）组、高剂量生酸橙（FA-H）组、低剂量炒麦麸酸橙（Bran-L）组、高剂量炒麦麸酸橙（Bran-H）组、低剂量炒麦麸和蜂蜜酸橙（Honey-L）组和高剂量炒麦麸和蜂蜜酸橙（Honey-H）组。FD 大鼠模型通过半饥饿、尾部阻尼、刺激、疲劳强制运动建立。比较各组体重、胃排空率和肠推进率、血清瘦素、胃动素、血管活性肠肽（VIP）、胃泌素、降钙素基因相关肽（CGRP）、胃饥饿素和胆囊收缩素水平的变化。
在 FD 模型组中，体重、胃排空率和肠推进率显著下降，瘦素、VIP 和 CGRP 表达增加，胃动素、胃泌素、胃饥饿素和胆囊收缩素表达显著下降。低剂量炒麦麸酸橙治疗显著逆转了这些作用。
在 FD 大鼠模型中，低剂量炒麦麸酸橙增加了胃肠动力和胃肠激素水平。
