DNA结合分子门控和非门控下DNA的单分子电导

Single-molecule conductance of DNA gated and ungated by DNA-binding molecules.

作者信息

Harashima Takanori, Kojima Chie, Fujii Shintaro, Kiguchi Manabu, Nishino Tomoaki

机构信息

Department of Chemistry, School of Science, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo 152-8551, Japan.

Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan.

出版信息

Chem Commun (Camb). 2017 Sep 19;53(75):10378-10381. doi: 10.1039/c7cc02911j.

DOI:10.1039/c7cc02911j

PMID:28875207

Abstract

The single-molecule conductance of DNA was found to increase by over four fold upon intercalation, while the conductance nearly unaltered upon groove-binding. These effects are interpreted on the basis of the electronic interaction of the DNA-binding molecules with the stacked DNA bases.

摘要

发现DNA的单分子电导在嵌入时增加了四倍多，而在沟槽结合时电导几乎不变。这些效应是基于DNA结合分子与堆叠的DNA碱基之间的电子相互作用来解释的。