Deutsches Rheumaforschungszentrum Berlin (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.
Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie & Medizin Inselspital, University of Bern, Bern, Switzerland.
Eur J Immunol. 2018 Jan;48(1):161-167. doi: 10.1002/eji.201747100. Epub 2017 Sep 29.
Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation.
关于通过将幼稚 T 细胞过继转移到 Rag 小鼠中诱导肠道炎症是否需要 T 细胞中转录因子 T-bet 的表达，目前已经提供了相互矛盾的证据。在这里，我们正式表明 Rag 受体的肠道微生物群落组成决定了 T-bet 缺陷性 Th 细胞是否能够诱导结肠炎，并且我们已经解决了两种微生物群落的差异，即允许或不允许 T-bet 非依赖性结肠炎。我们的数据强调了微生物群在慢性肠道炎症发病机制中对特定 T 细胞分化程序的主导作用。
