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纳米医学在癌症药物传递中的应用前景。

Promising effects of nanomedicine in cancer drug delivery.

机构信息

a Research and Development , Insys Therapeutics, Inc , Chandler , AZ , USA.

出版信息

J Drug Target. 2018 Apr;26(4):319-324. doi: 10.1080/1061186X.2017.1377207. Epub 2017 Sep 18.

Abstract

Successful ushering of nanomedicine has shown immense potential in advancing cancer treatment regimens. The unique characteristics of nanoparticles such as their optimal size, shape, efficient surface to volume ratio, surfaces that can be optimally tailored make them very attractive delivery candidates for highly hydrophobic chemotherapeutic agents. Moreover, their inherent capacity to encapsulate these drugs and enhance their solubility profiles offers them unique advantages over conventional treatments. Surface modification with targeting ligands, increased intracellular uptake and prolonged circulation profiles in vivo establish their overall superiority over other treatment regimens. This article attempts to highlight some of these salient features of nanoparticles as drug delivery agents, which makes them more attractive in terms of providing promising opportunities in targeted drug delivery.

摘要

纳米医学的成功应用显示出在推进癌症治疗方案方面具有巨大的潜力。纳米粒子具有独特的特性,如最佳尺寸、形状、高效的表面积与体积比、可以最佳定制的表面,这使得它们成为高度疏水性化疗药物的非常有吸引力的递药候选物。此外,它们封装这些药物并提高其溶解度谱的固有能力使它们具有优于传统治疗方法的独特优势。通过靶向配体进行表面修饰、增加细胞内摄取和延长体内循环时间,确立了它们相对于其他治疗方案的整体优势。本文试图强调纳米粒子作为药物递送剂的一些显著特征,这使得它们在提供靶向药物递送方面更具吸引力。

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