Division of Respiratory Viruses, Center for Infectious Diseases, National Institutes of Health, Korea Centers for Disease Control & Prevention, Cheongju-si, Chungbuk, Korea.
Health and Environment Institute of Gwangju, Gwangju, Korea.
J Med Virol. 2018 Jan;90(1):61-66. doi: 10.1002/jmv.24935. Epub 2017 Sep 25.
Recent years have seen a high incidence of mumps, which is generally diagnosed based on clinical features, especially parotitis, without laboratory confirmation in Korea. To better understand the epidemiology of mumps in Korean children, we investigated sporadic suspected mumps cases with parotitis. In total, 237 buccal swabs or throat swabs collected from children with parotitis who had been clinically diagnosed with mumps were tested using real-time PCR for the detection of six viruses (Epstein-Barr virus, Human herpesvirus 6, Mumps virus, Human parainfluenza virus-1, -2, -3, Human adenovirus, Human bocavirus). Among 237 parotitis cases, 87 (36.7%) were positive for at least one virus; a single infection was observed in 73 (83.9%) cases, and co-infections were detected in 14 (16.1%) cases. Epstein-Barr virus was most frequent (20.7%), followed by human herpesvirus 6 (8.0%), mumps virus (5.5%), human parainfluenza virus-3 (4.6%), human adenovirus (4.2%), and human bocavirus (0.4%). These data suggested that the sporadic suspected mumps in the children might be related to other respiratory viruses rather than to the mumps virus. Our findings also indicate the limitation of clinical diagnosis without laboratory confirmation for mumps and thus highlight the importance of laboratory testing in suspected mumps cases.
近年来，流行性腮腺炎发病率较高，在韩国通常根据临床特征（尤其是腮腺炎）进行诊断，而无需实验室确认。为了更好地了解韩国儿童流行性腮腺炎的流行病学，我们对有腮腺炎症状的散发性疑似流行性腮腺炎病例进行了调查。共采集了 237 份经临床诊断为流行性腮腺炎的儿童的口腔或咽喉拭子，使用实时 PCR 检测六种病毒（EB 病毒、人类疱疹病毒 6 型、腮腺炎病毒、人类副流感病毒 1 型、2 型、3 型、人类腺病毒、人类博卡病毒）。在 237 例腮腺炎病例中，至少有一种病毒阳性的有 87 例（36.7%）；73 例（83.9%）为单一感染，14 例（16.1%）为混合感染。最常见的是 EB 病毒（20.7%），其次是人类疱疹病毒 6 型（8.0%）、腮腺炎病毒（5.5%）、人类副流感病毒 3 型（4.6%）、人类腺病毒（4.2%）和人类博卡病毒（0.4%）。这些数据表明，儿童中散发性疑似流行性腮腺炎可能与其他呼吸道病毒有关，而不是与腮腺炎病毒有关。我们的发现还表明，临床诊断而无实验室确认对流行性腮腺炎的局限性，因此突出了在疑似流行性腮腺炎病例中进行实验室检测的重要性。
