撒哈拉以南非洲人群中瘦素与脂联素比值与代谢综合征的关联。
Association of the leptin-to-adiponectin ratio with metabolic syndrome in a sub-Saharan African population.
作者信息
Ayina Clarisse Noël A, Endomba Francky Teddy A, Mandengue Samuel Honoré, Noubiap Jean Jacques N, Ngoa Laurent Serge Etoundi, Boudou Philippe, Gautier Jean-François, Mbanya Jean Claude, Sobngwi Eugene
机构信息
Department of Animal Science, Faculty of Science, University of Douala, Douala, Cameroon.
Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Science, University of Yaoundé I, Yaoundé, Cameroon.
出版信息
Diabetol Metab Syndr. 2017 Sep 5;9:66. doi: 10.1186/s13098-017-0265-6. eCollection 2017.
BACKGROUND
Worldwide there is an increased prevalence of metabolic syndrome mainly due to life-style modifications, and Africans are not saved of this situation. Many markers have been studied to predict the risk of this syndrome but the most used are leptin and adiponectin. Data on these metabolic markers are scare in Africa and this study aimed to assess the association between the leptin-to-adiponectin ratio (LAR) with metabolic syndrome in a Cameroonian population.
METHODS
This was a cross-sectional study that included 476 adults among a general population of Cameroon. Data collected concerned the body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, plasma lipids, adiponectin, leptin, insulin and homeostasis model for assessment of insulin resistance (HOMA-IR). To assess correlations we used Spearman's analyses and association of the studied variables with metabolic syndrome were done using binary logistic regression analysis.
RESULTS
The leptin to adiponectin ratio was significantly and positively correlated with the body mass index (r = 0.669, p < 0.0001), waist circumference (r = 0.595, p < 0.0001), triglycerides (r = 0.190, p = 0.001), insulin levels (r = 0.333, p < 0.0001) and HOMA-IR (r = 0.306, p < 0.0001). Binary logistic regression analysis revealed that leptin, adiponectin and LAR were significantly associated with metabolic syndrome with respective unadjusted OR of 1.429, 0.468 and 1.502. After adjustment, for age and sex, the associations remained significative; LAR was also found to be significantly associated with metabolic syndrome (OR = 1.573, p value =0.000) as well as lower levels of adiponectin (OR = 0.359, p value =0.000) and higher levels of leptin (OR = 1.469, p value =0.001).
CONCLUSION
This study revealed that LAR is significantly associated with metabolic syndrome in sub-Saharan African population, independently to age and sex.
背景
在全球范围内，主要由于生活方式的改变，代谢综合征的患病率有所上升，非洲人也未能幸免。人们已经研究了许多标志物来预测这种综合征的风险，但最常用的是瘦素和脂联素。在非洲，关于这些代谢标志物的数据很少，本研究旨在评估喀麦隆人群中瘦素与脂联素比值（LAR）与代谢综合征之间的关联。
方法
这是一项横断面研究，纳入了喀麦隆普通人群中的476名成年人。收集的数据包括体重指数、腰围、收缩压、舒张压、空腹血糖、血脂、脂联素、瘦素、胰岛素以及评估胰岛素抵抗的稳态模型（HOMA-IR）。为了评估相关性，我们使用了Spearman分析，并使用二元逻辑回归分析来研究变量与代谢综合征之间的关联。
结果
瘦素与脂联素的比值与体重指数（r = 0.669，p < 0.0001）、腰围（r = 0.595，p < 0.0001）、甘油三酯（r = 0.190，p = 0.001）、胰岛素水平（r = 0.333，p < 0.0001）和HOMA-IR（r = 0.306，p < 0.0001）显著正相关。二元逻辑回归分析显示，瘦素、脂联素和LAR与代谢综合征显著相关，各自的未调整OR分别为1.429、0.468和1.502。在对年龄和性别进行调整后，这些关联仍然显著；LAR也被发现与代谢综合征显著相关（OR = 1.573，p值 = 0.000），以及较低水平的脂联素（OR = 0.359，p值 = 0.000）和较高水平的瘦素（OR = 1.469，p值 = 0.001）。
结论
本研究表明，在撒哈拉以南非洲人群中，LAR与代谢综合征显著相关，独立于年龄和性别。
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