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1995 - 2011年卢旺达麻风病病例发现趋势:对17年实验室数据的分析

Trends in leprosy case detection in Rwanda, 1995-2011: analysis of 17 years of laboratory data.

作者信息

Uwimana Innocent, Bizimungu Nestor, Ingabire Fabrice, Mukamukwiye Elyse, Sharangabo Odette, Ngabonziza Semuto C, Kamanzi Elaine

机构信息

School of Public Health, National University of Rwanda, Field Epidemiology and Laboratory Program (FELTP), Kigali, Rwanda.

Rwanda Biomedical Centre/Biomedical Services, National Reference Laboratory Division, Kigali, Rwanda.

出版信息

Afr J Lab Med. 2017 Feb 28;6(1):426. doi: 10.4102/ajlm.v6i1.426. eCollection 2017.

DOI:10.4102/ajlm.v6i1.426
PMID:28879146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5523925/
Abstract

BACKGROUND

Leprosy, or Hansen's disease, is a chronic, infectious disease caused by . It remains one of the leading causes of deformity and physical disability.

OBJECTIVE

We analysed laboratory records to assess trends in prevalence rates and case detection rates (CDRs) in Rwanda.

METHODS

A retrospective review of detected leprosy cases from the records of the Rwanda National Reference Laboratory over a 17-year period (1995-2011) was conducted. Skin biopsy samples were analysed microscopically using Ziehl-Neelsen staining technique to identify

RESULTS

Cumulatively, 266 suspected cases were reported between 1995 and 2011. Of the suspected cases, 77 (28.9%) were laboratory confirmed as having leprosy. Among detected cases, 59 (76.6%) were men and 18 (23.4%) women. The male:female ratio was 3:1. There were 77 registered leprosy cases over the 17-year period of the study, and the prevalence rate was 0.005 per 10 000 population. A gradual decrease in the prevalence rate was observed from 0.015 per 10 000 population in 2003 to 0.003 per 10 000 population in 2010. From 1995 to 2011, the CDR did not exceed one per 10 000 population.

CONCLUSION

This laboratory review demonstrates a declining trend in prevalence rates and CDR during the period of the study. Early case detection and a sustainable leprosy control programme remain the cornerstones of reducing the physical and socio-economic burden of leprosy in Rwanda.

摘要

背景

麻风病,即汉森氏病,是一种由……引起的慢性传染病。它仍然是导致畸形和身体残疾的主要原因之一。

目的

我们分析实验室记录以评估卢旺达麻风病患病率和病例检出率(CDR)的趋势。

方法

对卢旺达国家参考实验室17年期间(1995 - 2011年)记录的已检测麻风病病例进行回顾性研究。使用齐-尼氏染色技术对皮肤活检样本进行显微镜分析以鉴定……

结果

1995年至2011年累计报告266例疑似病例。在这些疑似病例中,77例(28.9%)经实验室确诊为麻风病。在确诊病例中,男性59例(76.6%),女性18例(23.4%)。男女比例为3:1。在该研究的17年期间共有77例登记麻风病病例,患病率为每10000人口0.005例。患病率从2003年的每10000人口0.015例逐渐下降至2010年的每10000人口0.003例。1995年至2011年,病例检出率未超过每10000人口1例。

结论

该实验室回顾显示在研究期间患病率和病例检出率呈下降趋势。早期病例发现和可持续的麻风病控制项目仍然是减轻卢旺达麻风病身体和社会经济负担的基石。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25b7/5523925/4bb9fb821d7a/AJLM-6-1-426-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25b7/5523925/c7f93b728979/AJLM-6-1-426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25b7/5523925/e7f33ccc255c/AJLM-6-1-426-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25b7/5523925/4bb9fb821d7a/AJLM-6-1-426-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25b7/5523925/c7f93b728979/AJLM-6-1-426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25b7/5523925/e7f33ccc255c/AJLM-6-1-426-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25b7/5523925/4bb9fb821d7a/AJLM-6-1-426-g003.jpg

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Leprosy: a review of laboratory and therapeutic aspects--part 2.麻风病:实验室及治疗方面的综述——第二部分
An Bras Dermatol. 2014 May-Jun;89(3):389-401. doi: 10.1590/abd1806-4841.20142460.
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Leprosy Elimination: Progress and Challenges in Nigeria; Kaduna State TB and Leprosy Control Programme as a Case Study.尼日利亚的麻风病消除:进展与挑战;以卡杜纳州结核病和麻风病控制项目为例
2000 年至 2019 年巴西南部低流行地区麻风病的流行病学特征。
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Geographical distribution and prevalence of podoconiosis in Rwanda: a cross-sectional country-wide survey.卢旺达象皮病的地理分布和流行情况:一项全国性横断面调查。
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