Schmidt Martin J, Kolecka Malgorzata, Kirberger Robert, Hartmann Antje
Department of Veterinary Clinical Sciences, Clinic for Small Animals, Justus-Liebig-University Giessen, Giessen, Germany.
Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
Front Vet Sci. 2017 Aug 22;4:137. doi: 10.3389/fvets.2017.00137. eCollection 2017.
The nature of ventriculomegaly in dogs is still a matter of debate. Signs of increased intraventricular pressure and atrophy of the cerebral white matter have been found in dogs with ventriculomegaly, which would imply increased intraventricular pressure and, therefore, a pathological condition, i.e., to some extent. Reduced periventricular blood flow was found in people with high elevated intraventricular pressure. The aim of this study was to compare periventricular brain perfusion in dogs with and without ventriculomegaly using perfusion weighted-magnetic-resonance-imaging to clarify as to whether ventriculomegaly might be associated with an increase in intraventricular pressure. Perfusion was measured in 32 Cavalier King Charles spaniels (CKCS) with ventriculomegaly, 10 CKCSs were examined as a control group. Cerebral blood flow (CBF) was measured using free-hand regions of interest (ROI) in five brain regions: periventricular white matter, caudate nucleus, parietal cortex, hippocampus, and thalamus. CBF was significantly lower in the periventricular white matter of the dogs with ventriculomegaly ( = 0.0029) but not in the other ROIs. Reduction of periventricular CBF might imply increase of intraventricular pressure in ventriculomegaly.
犬脑室扩大的本质仍存在争议。在患有脑室扩大的犬中发现了脑室内压升高和脑白质萎缩的迹象，这意味着脑室内压升高，因此在某种程度上是一种病理状况。在脑室内压大幅升高的人群中发现脑室周围血流减少。本研究的目的是使用灌注加权磁共振成像比较患有和未患有脑室扩大的犬的脑室周围脑灌注情况，以阐明脑室扩大是否可能与脑室内压升高有关。对32只患有脑室扩大的查理士王小猎犬（CKCS）进行了灌注测量，将10只CKCS作为对照组进行检查。使用徒手感兴趣区（ROI）在五个脑区测量脑血流量（CBF）：脑室周围白质、尾状核、顶叶皮质、海马体和丘脑。患有脑室扩大的犬的脑室周围白质中的CBF显著降低（=0.0029），但在其他ROI中没有降低。脑室周围CBF的降低可能意味着脑室扩大时脑室内压升高。
