Lin M T, Nguyen B T, Binh T V, Be T V, Chiang T Y, Tseng L H, Yang Y C, Lin K H, Chen Y -C
Departments of Oncology, Hematology Center, Ho Chi Minh City, Veitnam, Vietnam.
Blood Transfusion Hematology Center, Ho Chi Minh City, Veitnam, Vietnam.
Arch Virol. 1997 Jul;142(7):1429-1440. doi: 10.1007/s007050050170.
Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confirmed in 6 patients (9.1%) by Western blot analysis and/or polymerase chain reaction. Phylogenetic analysis revealed that long terminal repeat sequences of HTLV-II proviruses from 5 thalassemic patients in Vietnam belonged to the same phylogenetic subgroup of HTLV-IIb as those from intravenous drug abusers in North America and Europe. These data shed light on the route of introducing HTLV-II into Vietnam.
在越南南部胡志明市输血血液学中心，通过颗粒凝集试验对总共66例重型地中海贫血患者进行了抗人I/II型嗜T淋巴细胞病毒（HTLV-I/II）抗体筛查，这些患者接受了来自有偿献血者的多次输血。通过蛋白质印迹分析和/或聚合酶链反应在6例患者（9.1%）中确诊为HTLV-II感染。系统发育分析显示，来自越南5例地中海贫血患者的HTLV-II前病毒长末端重复序列与来自北美和欧洲静脉注射吸毒者的序列属于HTLV-IIb的同一系统发育亚组。这些数据揭示了HTLV-II传入越南的途径。
