Szcześniak Dorota Maria, Jawiarczyk-Przybyłowska Aleksandra, Matusiak Łukasz, Bolanowska Anna, Maciaszek Julian, Siemińska Małgorzata, Rymaszewska Joanna, Bolanowski Marek
Wroclaw Medical University.
Endokrynol Pol. 2017;68(5):524-532. doi: 10.5603/EP.a2017.0044. Epub 2017 Sep 7.
The study aimed to evaluate the psychological profile of patients with acromegaly in comparison to other chronic diseases such as non-functioning pituitary adenomas, Cushing disease, and plaque psoriasis, and to a healthy control group.
A total sample of 153 participants in clinical groups underwent a cross-sectional assessment including the quality of life (AcroQoL, WHOQoL-BREF), psychiatric morbidity (GHQ-28), and the acceptance of illness (AIS), as well as 65 participants in the healthy control group.
The whole study sample had a predominance of urban married females (61%) with medium level of education (41%). Patients with acromegaly were diagnosed significantly later than patients from other clinical groups, after the onset of the first symptoms. Acromegaly was related to the presence of more symptoms of anxiety and insomnia, and poorer social relationships compared with the general population but not more than in other chronic diseases. A better quality of life score in all domains of WHOQoL-BREF was associated with a better score on the acceptance of illness scale and lower scores on GHQ-28.
Psychiatric morbidity, mainly anxiety and insomnia, occurs in 50% of patients with acromegaly. However, the psychological wellbeing and mood seem to be related to other factors such as the acceptance of the illness. Thus, concerning the diagnosis, treatment, and monitoring of acromegaly an interdisciplinary approach, taking into account psychological and psychiatric consultation, is needed.
本研究旨在评估肢端肥大症患者与其他慢性疾病（如无功能垂体腺瘤、库欣病和斑块状银屑病）患者以及健康对照组相比的心理状况。
临床组的153名参与者接受了横断面评估，包括生活质量（肢端肥大症生活质量量表、世界卫生组织生活质量简表）、精神疾病发病率（一般健康问卷-28项）和疾病接受度（疾病接受度量表），健康对照组有65名参与者。
整个研究样本以城市已婚女性为主（61%），教育程度中等（41%）。肢端肥大症患者在首次出现症状后被诊断出的时间明显晚于其他临床组的患者。与普通人群相比，肢端肥大症与更多的焦虑和失眠症状以及更差的社会关系有关，但并不比其他慢性疾病更严重。世界卫生组织生活质量简表所有领域的生活质量得分越高，疾病接受度量表得分越高，一般健康问卷-28项得分越低。
50%的肢端肥大症患者存在精神疾病，主要是焦虑和失眠。然而，心理健康和情绪似乎与其他因素有关，如对疾病的接受度。因此，在肢端肥大症的诊断、治疗和监测方面，需要一种跨学科的方法，考虑心理和精神科会诊。
