Program in Metabolic Biology, Nutritional Sciences &Toxicology, University of California, Berkeley, Berkeley, California, USA.
Nat Struct Mol Biol. 2017 Sep 7;24(9):687-688. doi: 10.1038/nsmb.3461.
The robustness of the circadian clock deteriorates with aging. Two new studies show that aging reprograms the circadian transcriptome in a cell-type-dependent manner and that such rewiring can be reversed by caloric restriction.
生物钟的稳健性随着衰老而恶化。两项新的研究表明，衰老以细胞类型依赖的方式重新编程生物钟的转录组，这种重布线可以通过热量限制来逆转。
