Ashraf Waseem, Ibrahim Abdulkhaleg, Alhosin Mahmoud, Zaayter Liliyana, Ouararhni Khalid, Papin Christophe, Ahmad Tanveer, Hamiche Ali, Mély Yves, Bronner Christian, Mousli Marc
Laboratory of Biophotonics and Pharmacology, Faculty of Pharmacy, University of Strasbourg, Illkirch, France.
Institute of Genetics and Molecular and Cellular Biology, University of Strasbourg, Illkirch-Graffenstaden, France.
Oncotarget. 2017 Apr 24;8(31):51946-51962. doi: 10.18632/oncotarget.17393. eCollection 2017 Aug 1.
Cancer is one of the deadliest diseases in the world causing record number of mortalities in both developed and undeveloped countries. Despite a lot of advances and breakthroughs in the field of oncology still, it is very hard to diagnose and treat the cancers at early stages. Here in this review we analyze the potential of Ubiquitin-like containing PHD and Ring Finger domain 1 (UHRF1) as a universal biomarker for cancers. UHRF1 is an important epigenetic regulator maintaining DNA methylation and histone code in the cell. It is highly expressed in a variety of cancers and is a well-known oncogene that can disrupt the epigenetic code and override the senescence machinery. Many studies have validated UHRF1 as a powerful diagnostic and prognostic tool to differentially diagnose cancer, predict the therapeutic response and assess the risk of tumor progression and recurrence. Highly sensitive, non-invasive and cost effective approaches are therefore needed to assess the level of UHRF1 in patients, which can be deployed in diagnostic laboratories to detect cancer and monitor disease progression.
癌症是世界上最致命的疾病之一，在发达国家和不发达国家都导致了创纪录的死亡人数。尽管肿瘤学领域取得了许多进展和突破，但在早期阶段诊断和治疗癌症仍然非常困难。在这篇综述中，我们分析了含PHD和环指结构域1的泛素样蛋白（UHRF1）作为癌症通用生物标志物的潜力。UHRF1是一种重要的表观遗传调节因子，可维持细胞中的DNA甲基化和组蛋白编码。它在多种癌症中高度表达，是一种著名的致癌基因，可破坏表观遗传密码并超越衰老机制。许多研究已证实UHRF1是一种强大的诊断和预后工具，可用于鉴别诊断癌症、预测治疗反应以及评估肿瘤进展和复发的风险。因此，需要高度灵敏、无创且经济高效的方法来评估患者体内UHRF1的水平，这些方法可应用于诊断实验室以检测癌症并监测疾病进展。
