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本文引用的文献

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Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate.RAD51基因rs1801321与孕妇吸烟之间的相互作用作为非综合征性唇裂伴或不伴腭裂的风险因素。
Am J Med Genet A. 2016 Feb;170A(2):536-539. doi: 10.1002/ajmg.a.37281. Epub 2015 Oct 27.
2
Taurodontism in patients with nonsyndromic cleft lip and palate in a Brazilian population: a case control evaluation with panoramic radiographs.巴西人群中非综合征性唇腭裂患者的牛牙症:一项使用全景X线片的病例对照评估
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):744-50. doi: 10.1016/j.oooo.2015.08.005. Epub 2015 Aug 12.
3
A post GWAS association study of SNPs associated with cleft lip with or without cleft palate in submucous cleft palate.一项关于与黏膜下腭裂伴或不伴唇裂相关的单核苷酸多态性(SNP)的全基因组关联研究(GWAS)后关联研究。
Am J Med Genet A. 2015 Mar;167A(3):670-3. doi: 10.1002/ajmg.a.36891.
4
Risk of nonsyndromic cleft lip and palate in relatives of women with breast cancer.乳腺癌女性亲属患非综合征性唇腭裂的风险。
Am J Med Genet A. 2014 Jan;164A(1):270-1. doi: 10.1002/ajmg.a.36186. Epub 2013 Nov 20.
5
A 25-year review of cases with submucous cleft palate.一项关于黏膜下腭裂病例的25年回顾。
Int J Pediatr Otorhinolaryngol. 2013 Jul;77(7):1183-5. doi: 10.1016/j.ijporl.2013.04.033. Epub 2013 May 21.
6
Polymorphisms in FGF12, VCL, CX43 and VAX1 in Brazilian patients with nonsyndromic cleft lip with or without cleft palate.巴西非综合征性唇裂伴或不伴腭裂患者中 FGF12、VCL、CX43 和 VAX1 的多态性。
BMC Med Genet. 2013 May 16;14:53. doi: 10.1186/1471-2350-14-53.
7
Age of diagnosis and evaluation of consequences of submucous cleft palate.腭裂的诊断年龄及对其后果的评估
Int J Pediatr Otorhinolaryngol. 2013 Jun;77(6):1019-24. doi: 10.1016/j.ijporl.2013.03.036. Epub 2013 Apr 30.
8
Non syndromic cleft lip and palate: relationship between sex and clinical extension.非综合征性唇腭裂:性别与临床分型的关系。
Braz J Otorhinolaryngol. 2012 Oct;78(5):116-20. doi: 10.5935/1808-8694.20120018.
9
The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.来自巴西不同地区的个体的基因组祖先比预期的更为统一。
PLoS One. 2011 Feb 16;6(2):e17063. doi: 10.1371/journal.pone.0017063.
10
Cleft lip and palate: understanding genetic and environmental influences.唇腭裂:了解遗传和环境的影响。
Nat Rev Genet. 2011 Mar;12(3):167-78. doi: 10.1038/nrg2933.

巴西人群中悬雍垂裂的发病率及其与腭黏膜下裂和口腔腭裂家族史的关系。

Incidence of bifid uvula and its relationship to submucous cleft palate and a family history of oral cleft in the Brazilian population.

作者信息

Sales Sizina Aguiar G, Santos Maria Luiza, Machado Renato Assis, Dias Verônica Oliveira, Nascimento Jairo Evangelista, Swerts Mario Sérgio Oliveira, Júnior Hercílio Martelli, Martelli Daniella Reis Barbosa

机构信息

Universidade Estadual de Montes Claros (Unimontes), Faculdade de Medicina, Montes Claros, MG, Brazil; Universidade Estadual de Montes Claros (Unimontes), Programa de Pós-graduação em Cuidado Primário em Saúde, Montes Claros, MG, Brazil.

Universidade Estadual de Montes Claros (Unimontes), Faculdade de Odontologia, Montes Claros, MG, Brazil.

出版信息

Braz J Otorhinolaryngol. 2018 Nov-Dec;84(6):687-690. doi: 10.1016/j.bjorl.2017.08.004. Epub 2017 Aug 24.

DOI:10.1016/j.bjorl.2017.08.004
PMID:28886940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9442829/
Abstract

INTRODUCTION

Bifid uvula is a frequently observed anomaly in the general population and can be regarded as a marker for submucous cleft palate.

OBJECTIVE

In this study aimed to determine the frequency of bifid uvula and submucous cleft palate and their relationship with oral clefts in a Brazilian population.

METHODS

We conducted a transversal, descriptive and quantitative study of 1206 children between August 2014 and December 2015. A clinical examination of the children was conducted by means of inspection of the oral cavity with the aid of a tongue depressor and directed light. After the clinical examination in children, parents answered a questionnaire with questions about basic demographic information and their family history of oral clefts in their first-degree relatives. After application of the questionnaires, the information collected was archived in a database and analyzed by the statistical program SPSS version 19.0, by applying Chi-Square tests. Values with p<0.05 were considered statistically significant.

RESULTS

Of the 1206 children included in this study, 608 (50.40%) were female and 598 (49.60%) were male (p=0.773). The average age of children was 3.75 years (standard deviation±3.78 years). Of the 1206 children studied, 6 (0.5%) presented with bifid uvula. Submucosal cleft palate was not found in any child. When the family histories of children were examined for the presence of nonsyndromic cleft lip and/or cleft palate, no first degree relatives presented with the congenital anomaly.

CONCLUSION

This study revealed that the incidence of bifid uvula and submucous cleft palate in this population was quite similar to previously reported incidence rates. Our study suggests an intensification of new reviews, with broader and diverse populations, seeking to associate the occurrence of bifid uvula, submucous cleft palate and oral clefts.

摘要

引言

悬雍垂裂是普通人群中常见的一种异常情况,可被视为黏膜下腭裂的一个标志。

目的

本研究旨在确定巴西人群中悬雍垂裂和黏膜下腭裂的发生率及其与口腔裂隙的关系。

方法

我们在2014年8月至2015年12月期间对1206名儿童进行了一项横断面、描述性和定量研究。借助压舌板和直射光对儿童口腔进行检查,从而对儿童进行临床检查。在对儿童进行临床检查后,家长回答了一份问卷,问卷内容涉及基本人口统计学信息以及其一级亲属的口腔裂隙家族史。问卷发放后,收集到的信息存档于数据库中,并通过统计软件SPSS 19.0应用卡方检验进行分析。p<0.05的值被认为具有统计学意义。

结果

本研究纳入的1206名儿童中,608名(50.40%)为女性,598名(49.60%)为男性(p = 0.773)。儿童的平均年龄为3.75岁(标准差±3.78岁)。在1206名研究儿童中,6名(0.5%)出现悬雍垂裂。未发现任何儿童患有黏膜下腭裂。当检查儿童的家族史中是否存在非综合征性唇裂和/或腭裂时,没有一级亲属患有这种先天性异常。

结论

本研究表明,该人群中悬雍垂裂和黏膜下腭裂的发生率与先前报道的发生率相当相似。我们的研究建议加强新的综述,纳入更广泛和多样化的人群,以探寻悬雍垂裂、黏膜下腭裂和口腔裂隙之间的关联。