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从髋关节植入物腐蚀的锥形连接部释放的金属物种的化学形态：患者组织的同步加速器分析。

The Chemical Form of Metal Species Released from Corroded Taper Junctions of Hip Implants: Synchrotron Analysis of Patient Tissue.

机构信息

Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital, Stanmore, United Kingdom.

Diamond Light Source, Harwell Science and Innovation Campus, Didcot, United Kingdom.

出版信息

Sci Rep. 2017 Sep 8;7(1):10952. doi: 10.1038/s41598-017-11225-w.

DOI:10.1038/s41598-017-11225-w
PMID:28887488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5591307/
Abstract

The mechanisms of metal release from the articulation at the head cup bearing and the tapered junctions of orthopaedic hip implants are known to differ and the debris generated varies in size, shape and volume. Significantly less metal is lost from the taper junction between Cobalt-Chromium-Molybdenum (CoCrMo) and Titanium (Ti) components (fretting-corrosion dominant mechanism), when compared to the CoCrMo bearing surfaces (wear-corrosion dominant mechanism). Corrosion particles from the taper junction can lead to Adverse Reactions to Metal Debris (ARMD) similar to those seen with CoCrMo bearings. We used synchrotron methods to understand the modes underlying clinically significant tissue reactions to Co, Cr and Ti by analysing viable peri-prosthetic tissue. Cr was present as CrO in the corroded group in addition to CrPO found in the metal-on-metal (MoM) group. Interestingly, Ti was present as TiO in an amorphous rather than rutile or anatase physical form. The metal species were co-localized in the same micron-scale particles as result of corrosion processes and in one cell type, the phagocytes. This work gives new insights into the degradation products from metal devices as well as guidance for toxicological studies in humans.

摘要

关节头杯轴承和矫形髋关节植入物的锥形连接处的金属释放机制已知不同，产生的碎片在大小、形状和体积上也有所不同。与 CoCrMo 承载表面（磨损-腐蚀占主导机制）相比，CoCrMo 和钛（Ti）组件之间的锥形连接处（微动腐蚀占主导机制）的金属损耗明显较少。来自锥形连接处的腐蚀颗粒会导致类似于 CoCrMo 轴承的金属碎屑相关不良反应（ARMD）。我们使用同步辐射方法通过分析有活力的假体周围组织来了解 Co、Cr 和 Ti 引起临床显著组织反应的模式。在腐蚀组中 Cr 以 CrO 的形式存在，而在金属对金属（MoM）组中则发现了 CrPO。有趣的是，Ti 以非晶态而不是金红石或锐钛矿的物理形态存在。由于腐蚀过程，金属物种在同一微米级颗粒中以及在一种细胞类型（吞噬细胞）中共同定位。这项工作为金属器械的降解产物提供了新的见解，并为人类的毒理学研究提供了指导。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a85a/5591307/0e7a4157abee/41598_2017_11225_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a85a/5591307/5d02a87e1f36/41598_2017_11225_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a85a/5591307/f1a97f2e73d6/41598_2017_11225_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a85a/5591307/eea42be52258/41598_2017_11225_Fig9_HTML.jpg
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