School of Materials Science and Engineering, State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Polytechnic University, Tianjin 300387, PR China.
School of Materials Science and Engineering, State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Polytechnic University, Tianjin 300387, PR China.
Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:303-313. doi: 10.1016/j.msec.2017.08.008. Epub 2017 Aug 3.
High antibacterial and skin-like hydrogels have always been the perfect wound dressing for human to protect wound from infection. Here, based on silk sericin, we design a series of nanoclay lithium magnesium silicate hydrate (LMSH) cross-linked semi-IPN sericin/poly(NIPAm/LMSH) (HSP) nanocomposite hydrogels and demonstrate advantages in serving as antibacterial wound dressing in comparison with gauze. Firstly, the effect of mass ratios of sericin/(sericin+NIPAm) upon pore structure, feasibility of mechanics and gas permeability of HSP nanocomposite hydrogels were evaluated. Then, the relationship between nanocomposite hydrogel and histological/antimicrobial properties was systematically analyzed. It was found that, the introduction of sericin increased internal pore size, leading to obvious transition from honeycomb to layered structure. Furthermore, as mass ratio of sericin/(sericin+NIPAm) is 20%, the wound healing area treated with nanocomposite hydrogels at 6th day reached up to 83%, 3 times of gauze, and almost recovered at 13th day. Especially, antibacterial mechanism can be thought to be the results that the macromolecular sericin embedded in the nanocomposite hydrogel adsorbed bacteria by charge interaction and micromolecular sericin dissociating out from nanocomposite hydrogels can be adsorbed onto bacteria.
具有高抗菌性和类似皮肤的水凝胶一直是人类保护伤口免受感染的理想伤口敷料。在这里，我们基于丝胶，设计了一系列纳米粘土锂镁硅水合物（LMSH）交联的半互穿网络丝胶/聚（NIPAm/LMSH）（HSP）纳米复合水凝胶，并证明了其作为抗菌伤口敷料的优势，优于纱布。首先，评估了丝胶/（丝胶+NIPAm）的质量比对 HSP 纳米复合水凝胶的孔结构、力学性能和透气性的影响。然后，系统分析了纳米复合水凝胶与组织学/抗菌性能的关系。结果表明，丝胶的引入增加了内部孔径，导致结构从蜂窝状向层状明显转变。此外，当丝胶/（丝胶+NIPAm）的质量比为 20%时，纳米复合水凝胶处理的伤口愈合面积在第 6 天达到 83%，是纱布的 3 倍，在第 13 天几乎完全愈合。特别是，抗菌机制可以认为是高分子丝胶通过电荷相互作用吸附细菌，以及从小分子丝胶从纳米复合水凝胶中解离出来并吸附在细菌上的结果。
