Zhang Kun, Ma Xuanxuan, Teng Da, Mao Ruoyu, Yang Na, Hao Ya, Wang Jianhua
Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Antibiotics (Basel). 2024 Sep 15;13(9):889. doi: 10.3390/antibiotics13090889.
Wound infections caused by often result in localized suppurative lesions that severely impede the healing process, so it is urgent to develop a dress with efficient antimicrobial and pro-healing functions. In this study, the bifunctional injectable hydrogel lactoferrin (Lf)/NZ2114/lithium magnesium silicate hydrogel (LMSH) was first successfully prepared through the electrostatic interaction method. The physical, biological, and efficacy properties are systematically analyzed with good shear-thinning capacity and biocompatibility. More importantly, it inhibits infection and promotes wound healing in a mouse wound infection model after 14 d treatment, and the bactericidal rate and healing rate were over 99.92% and nearly 100%, respectively. Meanwhile, the massive reduction of inflammatory cells, restoration of tissue structure, and angiogenesis in mice showed the anti-inflammatory and pro-healing properties of the hydrogel. The healed wounds showed thickening with more hair follicles and glands, suggesting that the hydrogel Lf/NZ2114/LMSH (Three in One) could be a better dressing candidate for the treatment of -induced wound infections.
由……引起的伤口感染通常会导致局部化脓性病变，严重阻碍愈合过程，因此开发一种具有高效抗菌和促进愈合功能的敷料迫在眉睫。在本研究中，首先通过静电相互作用法成功制备了双功能可注射水凝胶乳铁蛋白（Lf）/NZ2114/锂镁硅酸盐水凝胶（LMSH）。对其物理、生物学和功效特性进行了系统分析，具有良好的剪切变稀能力和生物相容性。更重要的是，在小鼠伤口感染模型中经过14天治疗后，它能抑制感染并促进伤口愈合，杀菌率和愈合率分别超过99.92%和近100%。同时，小鼠体内炎症细胞大量减少、组织结构恢复和血管生成表明了水凝胶的抗炎和促进愈合特性。愈合的伤口显示增厚，有更多的毛囊和腺体，表明水凝胶Lf/NZ2114/LMSH（三合一）可能是治疗……引起的伤口感染的更好敷料候选物。 （原文中“由……引起”以及“治疗……引起”处表述不完整，缺少具体内容）
