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κ-卡拉胶-藻红蛋白水凝胶对体外伤口愈合和生物学功能的影响。

The Influence of κ-Carrageenan-R-Phycoerythrin Hydrogel on In Vitro Wound Healing and Biological Function.

机构信息

Division of Fisheries Life Sciences, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea.

Institute of Fisheries Sciences, Pukyong National University, Gijang-gun, Busan 46041, Republic of Korea.

出版信息

Int J Mol Sci. 2023 Aug 2;24(15):12358. doi: 10.3390/ijms241512358.

DOI:10.3390/ijms241512358
PMID:37569731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10419105/
Abstract

Wound healing is widely recognized as a critical issue impacting the healthcare sector in numerous countries. The application of wound dressings multiple times in such instances can result in tissue damage, thereby increasing the complexity of wound healing. With the aim of tackling this necessity, in the present study, we have formulated a hydrogel using natural polysaccharide κ-carrageenan and phycobiliprotein R-phycoerythrin from . The formulated hydrogel κ-Carrageenan-R-Phycoerythrin (κ-CRG-R-PE) was analyzed for its antioxidant and antimicrobial activity. The wound healing potential of the κ-CRG-R-PE was evaluated in Hs27 cells by the wound scratch assay method. The hydrogel showed dose-dependent antioxidant activity and significant antimicrobial activity at 100 μg/mL concentration. κ-CRG-R-PE hydrogels promoted more rapid and complete wound closure than κ-Carrageenan (κ-CRG) hydrogel at 24 and 48 h. κ-CRG-R-PE hydrogels also filled the wound within 48 h of incubation, indicating that they positively affect fibroblast migration and wound healing.

摘要

伤口愈合是一个广泛受到关注的问题，对许多国家的医疗保健部门都有重要影响。在这种情况下，多次使用伤口敷料可能会导致组织损伤，从而增加伤口愈合的复杂性。为了解决这一需求，本研究采用天然多糖κ-卡拉胶和蓝藻藻红蛋白 R-藻红蛋白制备了水凝胶。对所制备的水凝胶κ-卡拉胶-R-藻红蛋白（κ-CRG-R-PE）进行了抗氧化和抗菌活性分析。通过划痕实验方法评估了 κ-CRG-R-PE 在 Hs27 细胞中的伤口愈合潜力。水凝胶在 100 μg/mL 浓度下表现出剂量依赖性的抗氧化活性和显著的抗菌活性。与 κ-卡拉胶（κ-CRG）水凝胶相比，κ-CRG-R-PE 水凝胶在 24 和 48 h 时能更迅速和完全地闭合伤口。κ-CRG-R-PE 水凝胶在孵育 48 h 内也能填满伤口，表明其能积极促进成纤维细胞迁移和伤口愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2873/10419105/e9b4438c68fa/ijms-24-12358-g006.jpg
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